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Review
. 2020 Dec:229:102722.
doi: 10.1016/j.autneu.2020.102722. Epub 2020 Sep 11.

Is there cardiac autonomic neuropathy in prediabetes?

Lindsay A Zilliox  1 , James W Russell  2
Affiliations
Review

Is there cardiac autonomic neuropathy in prediabetes?

Lindsay A Zilliox et al. Auton Neurosci. 2020 Dec.

Abstract

Although there is considerably more data showing an association between type 2 diabetes mellitus (T2DM) and autonomic neuropathy, accumulating evidence indicates that cardiovascular autonomic neuropathy (CAN) is common in persons with impaired glucose tolerance (IGT). Furthermore, CAN may occur early after a metabolic insult and obesity, especially among mean, and seems to play an important role in the early pathogenesis of CAN. Autonomic symptoms are common in subjects with IGT. In addition to defects in CAN, in subjects with IGT, there is impaired sudomotor function and abnormalities of endothelial peripheral vasoreactivity. At the present time, the only interventions that may be effective in preventing or reversing IGT associated autonomic neuropathy are lifestyle improvement. These include a tailored diet and exercise program. Other approaches that may be beneficial include modulation of oxidative stress and improvement of metabolic regulation in subjects with IGT. Interventions are most likely to be effective early in the course of disease and therefore it is extremely important to have early diagnosis of IGT and autonomic neuropathy.

Keywords: Autonomic; Diabetes; Impaired glucose tolerance; Neuropathy.

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Figures

Fig. 1.
Fig. 1.
Pattern of QSART abnormalities in subjects with IGT based on normative data for age and gender. From (Zilliox et al., 2011). Reproduced with permission.
See this image and copyright information in PMC

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