Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar;303(3):767-775.
doi: 10.1007/s00404-020-05822-w. Epub 2020 Oct 3.

Preoperative low hematocrit is an adverse prognostic biomarker in ovarian cancer

Junchen Chen  1   2 , Yi Li  3   4 , Heng Cui  5   6
Affiliations

Preoperative low hematocrit is an adverse prognostic biomarker in ovarian cancer

Junchen Chen et al. Arch Gynecol Obstet. 2021 Mar.

Abstract

Objective: The study aimed to investigate the prognostic value of preoperative hematocrit (HCT) on the survival of epithelial ovarian cancer (EOC) patients.

Methods: Patients who underwent primary debulking surgery (PDS) in our institution, from January 2010 to December 2015, were enrolled. The preoperative HCT, hemoglobin (Hb), tumor stage, ascites volume, age, albumin, BMI, ASA score, diabetes and other factors were collected and analyzed to find the risk factors for poor prognosis of EOC patients using Cox regression. Survival analysis was conducted with Kaplan-Meier method and log-rank test.

Results: 192 patients met the inclusion criteria. HCT < 35% (P = 0.031, HR: 1.715, 95% CI 1.050-2.802) was an independent risk factor for poor overall survival in patients. The mean survival time was 83.7 months in patients with preoperative HCT ≥ 35% and 61.7 months in patients with HCT < 35% (P = 0.002). Patients with low HCT (< 35%) had a poor prognosis compared with patients with normal HCT, specifically in the patients of stage III/IV, age ≥ 65 years, BMI ≥ 25.0 kg/m2, ascites volume ≤ 500 mL, ASA score < 3, albumin ≥ 35 g/L and nondiabetic. Low HCT was more likely to occur in patients with advanced stage (III/IV), anemia (Hb < 110 g/mL), low albumin (< 35 g/L), high ASA score (≥ 3) and platelet > 400 × 109/L.

Conclusions: Preoperative low HCT was a valuable predictor for EOC patients' poor prognosis, specifically in obese, nondiabetic, elder, advanced stage but having relatively good performance status patients.

Keywords: Hematocrit; Ovarian cancer; Prognosis; Survival.

PubMed Disclaimer

References

    1. Nie D, Gong H, Mao X, Li Z (2019) Systemic immune-inflammation index predicts prognosis in patients with epithelial ovarian cancer: a retrospective study. Gynecol Oncol 152(2):259–264. https://doi.org/10.1016/j.ygyno.2018.11.034 - DOI - PubMed
    1. Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL (2018) Ovarian cancer statistics, 2018. CA Cancer J Clin 68(4):284–296. https://doi.org/10.3322/caac.21456 - DOI - PubMed - PMC
    1. Scambia G, Ferrandina G (2018) A turning point in the fight against ovarian cancer? Lancet Oncol 19(2):154–156. https://doi.org/10.1016/s1470-2045(18)30005-6 - DOI - PubMed
    1. Rodriguez-Morales AJ, Sanchez E, Arria M, Vargas M, Piccolo C, Colina R, Franco-Paredes C (2007) Haemoglobin and haematocrit: the threefold conversion is also non valid for assessing anaemia in Plasmodium vivax malaria-endemic settings. Malar J 6:166. https://doi.org/10.1186/1475-2875-6-166 - DOI - PubMed - PMC
    1. Zhang X, Zhang F, Qiao W, Zhang X, Zhao Z, Li M (2018) Low Hematocrit is a strong predictor of poor prognosis in lung cancer patients. Biomed Res Int 2018:6804938. https://doi.org/10.1155/2018/6804938 - DOI - PubMed - PMC

Publication types

MeSH terms

LinkOut - more resources