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Review
. 2020 Nov;40(4):593-607.
doi: 10.1016/j.iac.2020.06.004. Epub 2020 Sep 12.

Biologics for Atopic Dermatitis

Mark Boguniewicz  1
Affiliations
Review

Biologics for Atopic Dermatitis

Mark Boguniewicz. Immunol Allergy Clin North Am. 2020 Nov.

Abstract

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that has become a global health problem. The pathophysiology of AD includes both skin barrier and immune abnormalities, with type 2 immune deviation central to several clinical phenotypes and underlying endotypes. Recognition of the persistent nature and systemic aspects of AD provides a rationale for treatment with a biologic. Dupilumab has been approved for patients 6 years of age and older with moderate to severe AD. Monoclonal antibodies are in phase 3 trials and may become part of a precision medicine approach to AD.

Keywords: Atopic dermatitis; Biologics; Dupilumab; Immune dysregulation; Lebrikizumab; Nemolizumab; Omalizumab; Tralokinumab.

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Conflict of interest statement

Conflict of interest M. Boguniewicz has served as a consultant for Regeneron and Sanofi-Genzyme.

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