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. 2020 Sep;11(3):378-386.
doi: 10.1007/s13193-020-01163-x. Epub 2020 Aug 14.

Single-Dose Prophylactic Antibiotic Versus Extended Usage for Four Days in Clean-Contaminated Oncological Surgeries: a Randomized Clinical Trial

Syed Nusrath  1 , Abhijit Nair  2 , Sridhar Dasu  1 , T Subramanyeshwar Rao  1 , K V V N Raju  1 , Basanth Kumar Rayani  2 , Vibhavari Milind Naik  2 , Sujit C Patnaik  1 , R Rajagopalan Iyer  1 , Ajesh Raj Saksena  1 , M Ramanuja Rao  1 , Salman Saifuddin  2 , Harini Narayanan  2 , Radha Rani Dandamudi  3 , Naresh Gupta  4
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Single-Dose Prophylactic Antibiotic Versus Extended Usage for Four Days in Clean-Contaminated Oncological Surgeries: a Randomized Clinical Trial

Syed Nusrath et al. Indian J Surg Oncol. 2020 Sep.

Abstract

The optimal duration of prophylactic antimicrobial usage in clean-contaminated elective oncological surgeries is not clear. This single-center randomized trial evaluated the effectiveness of single-dose antimicrobial prophylaxis in clean-contaminated surgeries for the reduction of surgical site infection (SSI). Between April 2018 and January 2019, 315 patients undergoing major oncological clean-contaminated surgeries where the gastrointestinal or genital tract was opened under controlled conditions were randomized into 2 groups i.e., single dose versus extended dose groups. The single dose group received a 1.5 g dose of cefuroxime immediately before surgery while the extended group received the same dose of cefuroxime thrice daily for 4 days from the day of surgery till postoperative day 3. In addition, patients undergoing esophageal and colorectal surgeries received metronidazole. The overall SSI rate of the single dose group was not significantly different from that of the extended group (11.3% vs. 14.7%, respectively, p 0.40), with absolute difference of 3.4% and relative risk of 0.85 (95% C.I, 0.59 to 1.22). The rate of remote site infection was also not different between the two groups (14.4% vs 10.2%, p 0.31) with absolute difference of 4.2% and relative risk 1.19 (95% C.I, 0.89 to 1.59). In univariate analysis, parameters like nodal dissection, colorectal surgery, smoking, and hospital stay were significantly associated with SSI. In multivariate analysis, age, smoking, nodal dissection, and hospital stay retained significance. Single-dose antimicrobial prophylaxis is as effective as extended usage for 4 days in the prevention of postoperative SSI in patients undergoing clean-contaminated major oncological surgeries. Trial was registered with the clinical trial registry of India (CTRI/2018/06/014344).

Keywords: Antibiotic; Perioperative; Prophylaxis; Surgery; Surgical site infection.

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References

    1. Burke JP. Infection control--a problem for patient safety. N Engl J Med. 2003;348:65–66. doi: 10.1056/NEJMhpr020557. - DOI - PubMed
    1. Centers for Disease Control and Prevention National Nosocomial Infections Surveillance (NNIS) System report: data summary from January 1992–June 2001, issued August 2001. Am J Infect Control. 2001;29:404–421. doi: 10.1067/mic.2001.119952. - DOI - PubMed
    1. Mohri Y, Tonouchi H, Kobayashi M, Nakai K, Kusunoki M, Mie Surgical Infection Research Group Randomized clinical trial of single- versus multiple-dose antimicrobial prophylaxis in gastric cancer surgery. Br J Surg. 2007;94:683–688. doi: 10.1002/bjs.5837. - DOI - PubMed
    1. Nelson RL, Gladman E, Barbateskovic M (2014) Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev (5):CD001181 - PMC - PubMed
    1. Clarke-Pearson DL, Geller EJ. Complications of hysterectomy. Obstet Gynecol. 2013;121:654–673. doi: 10.1097/AOG.0b013e3182841594. - DOI - PubMed

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