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Review
. 2020 Sep;11(3):538-548.
doi: 10.1007/s13193-020-01156-w. Epub 2020 Aug 3.

The Value of Lymphadenectomy Post-Neoadjuvant Therapy in Carcinoma Esophagus: a Review

Syed Nusrath  1 , Ajesh Raj Saxena  1 , K V V N Raju  1 , Sujith Patnaik  1 , T Subramanyeshwar Rao  1 , Naren Bollineni  1
Affiliations
Review

The Value of Lymphadenectomy Post-Neoadjuvant Therapy in Carcinoma Esophagus: a Review

Syed Nusrath et al. Indian J Surg Oncol. 2020 Sep.

Abstract

Lymph nodal metastasis is one of the most important prognostic factors determining survival in patients with carcinoma esophagus. Radical esophagectomy, with the resection of surrounding lymph nodes, is considered the prime treatment of carcinoma esophagus. An extensive lymphadenectomy improves the accuracy of staging and betters locoregional control, but its effect on survival is still not apparent and carries the disadvantage of increased morbidity. The extent of lymphadenectomy during esophagectomy also remains debatable, with many studies revealing contradictory results, especially in the era of neoadjuvant therapy. The pattern of distribution and the number of nodal metastasis are modified by neoadjuvant therapy. The paper reviews the existing evidence to determine whether increased lymph node yield improves oncological outcomes in patients undergoing esophagectomy with particular attention to those patients receiving neoadjuvant therapy.

Keywords: Esophagectomy; Lymphadenectomy; Neoadjuvant therapy.

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Conflict of interest statement

Conflict of InterestThe authors declare no conflicts of interest.

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