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. 2020 Sep 11:11:1053.
doi: 10.3389/fneur.2020.01053. eCollection 2020.

Myasthenia Gravis and COVID-19: Clinical Characteristics and Outcomes

Antonio E Camelo-Filho  1 , André M S Silva  1 , Eduardo P Estephan  1   2 , Antônio A Zambon  1 , Rodrigo H Mendonça  1 , Paulo V S Souza  3 , Wladimir B V R Pinto  3 , Acary S B Oliveira  3 , Iron Dangoni-Filho  1 , Ana F P Pouza  1   4 , Berenice C O Valerio  5 , Edmar Zanoteli  1
Affiliations

Myasthenia Gravis and COVID-19: Clinical Characteristics and Outcomes

Antonio E Camelo-Filho et al. Front Neurol. .

Abstract

Myasthenia gravis (MG), an autoimmune neuromuscular disorder, may be a risk factor for severe COVID-19. We conducted an observational retrospective study with 15 consecutive adult MG patients admitted with COVID-19 at four hospitals in São Paulo, Brazil. Most patients with MG hospitalized for COVID-19 had severe courses of the disease: 87% were admitted in the intensive care unit, 73% needed mechanical ventilation, and 30% died. Immunoglobulin use and the plasma exchange procedure were safe. Immunosuppressive therapy seems to be associated with better outcomes, as it might play a protective role.

Keywords: COVID-19; Myasthenia Gravis; SARS-CoV-2; immunosuppression; neuromuscular disorders.

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