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. 2020 Aug 18:11:565.
doi: 10.3389/fendo.2020.00565. eCollection 2020.

Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study

Maaike van Gerwen  1   2 , Mathilda Alsen  1 , Christine Little  1 , Joshua Barlow  1 , Leonard Naymagon  3 , Douglas Tremblay  3 , Catherine F Sinclair  1 , Eric Genden  1
Affiliations

Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study

Maaike van Gerwen et al. Front Endocrinol (Lausanne). .

Abstract

Coronavirus diseases (COVID-19) is associated with high rates of morbidity and mortality and worse outcomes have been reported for various morbidities. The impact of pre-existing hypothyroidism on COVID-19 outcomes remains unknown. The aim of the present study was to identify a possible association between hypothyroidism and outcomes related to COVID-19 including hospitalization, need for mechanical ventilation, and all-cause mortality. All patients with a laboratory confirmed COVID-19 diagnosis in March 2020 in a large New York City health system were reviewed. Of the 3703 COVID-19 positive patients included in present study, 251 patients (6.8%) had pre-existing hypothyroidism and received thyroid hormone therapy. Hypothyroidism was not associated with increased risk of hospitalization [Adjusted Odds Ratio (ORadj): 1.23 (95% Confidence Interval (CI): 0.88- 1.70)], mechanical ventilation [ORadj: 1.17 (95% CI: 0.81-1.69)] nor death [ORadj: 1.07 (95% CI: 0.75-1.54)]. This study provides insight into the role of hypothyroidism on the outcomes of COVID-19 positive patients, indicating that no additional precautions or consultations are needed. However, future research into the potential complications of COVID-19 on the thyroid gland and function is warranted.

Keywords: COVID-19; cohort; epidemiology; hypothyroidism; outcomes; survival.

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Figures

Figure 1
Figure 1
Overall survival in the propensity matched hypothyroidism- no hypothyroidism cohort.
See this image and copyright information in PMC

References

    1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in china: summary of a report of 72314 cases from the chinese center for disease control and prevention. Jama. (2020) 323:1239–42. 10.1001/jama.2020.2648 - DOI - PubMed
    1. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. . Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the lombardy region, Italy. Jama. (2020) 323:2195–8. 10.1001/jama.2020.5394 - DOI - PMC - PubMed
    1. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. (2020) 395:1054–62. 10.1016/S0140-6736(20)30566-3 - DOI - PMC - PubMed
    1. van Gerwen M, Alsen M, Little C, Barlow J, Genden E, Naymagon L, et al. Characteristics and outcomes of COVID-19 in New York City; a retrospective cohort study. J Med Virol. (2020). 10.1002/jmv.26337 - DOI - PMC - PubMed
    1. Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, et al. . Angiotensin-converting enzyme-2 (ACE2), SARS-CoV-2 and pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol. (2020). 10.1002/path.5471 - DOI - PMC - PubMed

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