Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 18:2020:9725979.
doi: 10.1155/2020/9725979. eCollection 2020.

Is There a Nonlinear Relationship between Serum Uric Acid and Lipids in a Hypertensive Population with eGFR ≥30 ml/min/1.73 m2? Findings from the China Hypertension Registry Study

Yu Yu  1 , Xiao Huang  1 , Minghui Li  1 , Congcong Ding  1 , Lihua Hu  1 , Xiao Zhong  1 , Wei Zhou  2 , Tao Wang  2 , Lingjuan Zhu  2 , Huihui Bao  1   2 , Xiaoshu Cheng  1   2
Affiliations

Is There a Nonlinear Relationship between Serum Uric Acid and Lipids in a Hypertensive Population with eGFR ≥30 ml/min/1.73 m2? Findings from the China Hypertension Registry Study

Yu Yu et al. Int J Endocrinol. .

Abstract

Background: Evidence regarding the nonlinear relationship between serum uric acid (SUA) and blood lipids in Chinese population with hypertension is limited. Therefore, the present study aimed to investigate whether there is a nonlinear association between SUA and lipids in Chinese hypertensive population with an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2.

Methods: A total of 13,355 hypertensive participants with eGFR ≥30 ml/min/1.73 m2 were selected from the Chinese Hypertension Registry Study. Multivariate linear regression was used to examine the linear relationship between SUA and lipids. Smooth curve fitting (penalized spline method) and threshold saturation effects were used to analyze the nonlinear association between SUA and lipids.

Results: In the fully adjusted model, the results showed a positive correlation between SUA and TG (β = 0.15; 95% CI: 0.14, 0.16) and LDL-C (β = 0.06; 95% CI: 0.05, 0.07), respectively. However, the relationship between SUA and HDL-C was nonlinear. The inflection point of SUA was 7.24 mg/dL. On the left side of the inflection point (<7.24 mg/dL), SUA was negatively associated with HDL-C (β = -0.02; 95% CI -0.02, -0.01). On the right side of the inflection point (≥7.24 mg/dL), SUA was not related to HDL-C (β = 0.01; 95% CI -0.01, 0.02).

Conclusion: After adjusting for all covariates, SUA was positively associated with TG and LDL-C. The relationship between SUA and HDL-C was nonlinear. The negative correlation between SUA and HDL-C only existed when the SUA was less than 7.24 mg/dL in a hypertensive population with eGFR ≥30 ml/min/1.73 m2.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The positive association between SUA and TG in a hypertensive population. Adjusted for age, sex, smoking, alcohol use, stroke, diabetes, antihypertensive drugs, lipid-lowering drugs, glucose-lowering drugs, BMI, SBP, DBP, Hcy, FBG, and eGFR.
Figure 2
Figure 2
The positive association between SUA and LDL-C in a hypertensive population. Adjusted for age, sex, smoking, alcohol use, stroke, diabetes, antihypertensive drugs, lipid-lowering drugs, glucose-lowering drugs, BMI, SBP, DBP, Hcy, FBG, and eGFR.
Figure 3
Figure 3
The nonlinear relationship between SUA and HDL-C in a hypertensive population. Adjusted for age, sex, smoking, alcohol use, stroke, diabetes, antihypertensive drugs, lipid-lowering drugs, glucose-lowering drugs, BMI, SBP, DBP, Hcy, FBG, and eGFR.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Mach F., Baigent C., Catapano A. L., et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Revista Española de Cardiología (English Edition) 2020;73(5):p. 403. doi: 10.1016/j.rec.2020.04.006. - DOI
    1. Bibbins-Domingo K., Grossman D. C., Curry S. J., et al. Statin use for the primary prevention of cardiovascular disease in adults: US preventive services task force recommendation statement. JAMA. 2016;316(19):1997–2007. - PubMed
    1. Feig D. I., Kang D.-H., Johnson R. J. Uric acid and cardiovascular risk. New England Journal of Medicine. 2008;359(17):1811–1821. doi: 10.1056/nejmra0800885. - DOI - PMC - PubMed
    1. Fang J., Alderman M. H. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971–1992. National Health and Nutrition Examination Survey. JAMA. 2000;283(18):2404–2410. doi: 10.1001/jama.283.18.2404. - DOI - PubMed
    1. Nagahama K., Iseki K., Inoue T., Touma T., Ikemiya Y., Takishita S. Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan. Hypertension Research. 2004;27(4):227–233. doi: 10.1291/hypres.27.227. - DOI - PubMed