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Review
. 2020 Sep 17:2020:8659802.
doi: 10.1155/2020/8659802. eCollection 2020.

Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic

Amir R Afshari  1 , Hamid Mollazadeh  1   2 , Amirhossein Sahebkar  3   4   5   6
Affiliations
Review

Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic

Amir R Afshari et al. J Oncol. .

Abstract

One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
The proposed mechanisms of action of minocycline against GBM.
See this image and copyright information in PMC

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