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Review
. 2020 Oct 1:6:32.
doi: 10.1186/s41016-020-00213-1. eCollection 2020.

Current knowledge of large vascular occlusion due to intracranial atherosclerosis: focusing on early diagnosis

He Li  1   2 , Peng Liu  1   2 , Pei Liu  1   2 , Weilong Hua  1   2 , Wenjin Yang  1   2 , Yongxin Zhang  1   2 , Lei Zhang  1   2 , Pengfei Xing  2 , Zifu Li  1   2 , Yongwei Zhang  2 , Bo Hong  1   2 , Pengfei Yang  1   2 , Jianmin Liu  1   2
Affiliations
Review

Current knowledge of large vascular occlusion due to intracranial atherosclerosis: focusing on early diagnosis

He Li et al. Chin Neurosurg J. .

Abstract

Intracranial atherosclerosis (ICAS)-related large vascular occlusion (LVO) was an intractable subtype of acute ischemic stroke (AIS), which always needed rescue angioplasty and stenting and complicated the procedure of endovascular recanalization. Diagnosing ICAS-LVO accurately and early was helpful for both clinical treatment and trials. Digital subtraction angiography (DSA) was unable to provide an early and rapid diagnosis of ICAS-LVO based on current studies. A variety of pre-DSA methods had been used to distinguish ICAS-LVO with other subtypes of ischemic stroke, such as medical histories, clinical presentations, computed tomography or angiography (CT/CTA), and magnetic resonance imaging (MRI/MRA). This article briefly reviewed the status quo of the diagnosis and treatment of ICAS-LVO and summarized early diagnostic methods of ICAS-LVO from different aspects.

Keywords: AIS; Acute ischemic stroke; Diagnosis; ICAS; ICAS-LVO; Intracranial atherosclerosis; LVO; Large vascular occlusion.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Traditional diagnosis work-flow of ICAS-LVO
Fig. 2
Fig. 2
New diagnosis work-flow which might improve the efficiency of diagnosing ICAS-LVO
See this image and copyright information in PMC

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