Roles of Biomarkers in Myocardial Fibrosis

doi:10.14336/AD.2020.0604

Review

. 2020 Oct 1;11(5):1157-1174.

doi: 10.14336/AD.2020.0604. eCollection 2020 Oct.

Roles of Biomarkers in Myocardial Fibrosis

Yuejia Ding¹, Yuan Wang¹, Wanqin Zhang¹, Qiujin Jia¹, Xiaoling Wang², Yanyang Li³, Shichao Lv^{1

4}, Junping Zhang¹

Affiliations

¹ 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
² 3Qian'an Hospital of Traditional Chinese Medicine, Qian'an 064400, China.
³ 4Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
⁴ 2Tianjin Key Laboratory of Traditional Research of TCM Prescription and Syndrome, Tianjin 300000, China.

PMID: 33014530
PMCID: PMC7505259
DOI: 10.14336/AD.2020.0604

Review

Roles of Biomarkers in Myocardial Fibrosis

Yuejia Ding et al. Aging Dis. 2020.

. 2020 Oct 1;11(5):1157-1174.

doi: 10.14336/AD.2020.0604. eCollection 2020 Oct.

Authors

Yuejia Ding¹, Yuan Wang¹, Wanqin Zhang¹, Qiujin Jia¹, Xiaoling Wang², Yanyang Li³, Shichao Lv^{1

4}, Junping Zhang¹

Affiliations

¹ 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
² 3Qian'an Hospital of Traditional Chinese Medicine, Qian'an 064400, China.
³ 4Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
⁴ 2Tianjin Key Laboratory of Traditional Research of TCM Prescription and Syndrome, Tianjin 300000, China.

PMID: 33014530
PMCID: PMC7505259
DOI: 10.14336/AD.2020.0604

Abstract

Myocardial fibrosis is observed in various cardiovascular diseases and plays a key role in the impairment of cardiac function. Endomyocardial biopsy, as the gold standard for the diagnosis of myocardial fibrosis, has limitations in terms of clinical application. Therefore, biomarkers have been recommended for noninvasive assessment of myocardial fibrosis. This review discusses the role of biomarkers in myocardial fibrosis from the perspective of collagen.

Keywords: biomarkers; collagen; myocardial fibrosis; review.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest All authors declare no conflicts of interest.

Figures

**Figure 1.**
The process of collagen synthesis and degradation.

**Figure 2.**
Biomarkers and pathological effects of myocardial fibrosis.

See this image and copyright information in PMC

Cited by

A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice.
Lee HL, Hee SW, Hsuan CF, Yang W, Huang JY, Lin YL, Hsu CN, Hwang JJ, Chen SM, Ding ZZ, Lee TY, Lin YC, Tsai FC, Su WL, Chueh LY, Hsieh ML, Chen CH, Mochly-Rosen D, Chang YC, Chuang LM. Lee HL, et al. Antioxidants (Basel). 2021 Mar 13;10(3):450. doi: 10.3390/antiox10030450. Antioxidants (Basel). 2021. PMID: 33805825 Free PMC article.
Honokiol Ameliorates Post-Myocardial Infarction Heart Failure Through Ucp3-Mediated Reactive Oxygen Species Inhibition.
Liu J, Tang M, Li T, Su Z, Zhu Z, Dou C, Liu Y, Pei H, Yang J, Ye H, Chen L. Liu J, et al. Front Pharmacol. 2022 Feb 21;13:811682. doi: 10.3389/fphar.2022.811682. eCollection 2022. Front Pharmacol. 2022. PMID: 35264952 Free PMC article.
^99mTc-labeled FAPI compounds for cancer and inflammation: from radiochemistry to the first clinical applications.
Boschi A, Urso L, Uccelli L, Martini P, Filippi L. Boschi A, et al. EJNMMI Radiopharm Chem. 2024 May 2;9(1):36. doi: 10.1186/s41181-024-00264-0. EJNMMI Radiopharm Chem. 2024. PMID: 38695960 Free PMC article. Review.
Treatment of cardiac fibrosis: from neuro-hormonal inhibitors to CAR-T cell therapy.
Morfino P, Aimo A, Castiglione V, Gálvez-Montón C, Emdin M, Bayes-Genis A. Morfino P, et al. Heart Fail Rev. 2023 Mar;28(2):555-569. doi: 10.1007/s10741-022-10279-x. Epub 2022 Oct 11. Heart Fail Rev. 2023. PMID: 36221014 Free PMC article. Review.
Single-Cell RNA Sequencing Reveals Distinct Cardiac-Derived Stromal Cell Subpopulations.
Hoffman JR, Jayaraman AR, Bheri S, Davis ME. Hoffman JR, et al. J Cardiovasc Dev Dis. 2022 Nov 1;9(11):374. doi: 10.3390/jcdd9110374. J Cardiovasc Dev Dis. 2022. PMID: 36354773 Free PMC article.

See all "Cited by" articles

References

1. Berk BC, Fujiwara K, Lehoux S (2007). ECM remodeling in hypertensive heart disease. J Clin Invest, 117:568-575. - PMC - PubMed
1. Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI (1988). Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res, 62:757-765. - PubMed
1. Medugorac I, Jacob R (1983). Characterisation of left ventricular collagen in the rat. Cardiovasc Res, 17:15-21. - PubMed
1. Eghbali M, Czaja MJ, Zeydel M, Weiner FR, Zern MA, Seifter S, et al. (1988). Collagen chain mRNAs in isolated heart cells from young and adult rats. J Mol Cell Cardiol, 20:267-276. - PubMed
1. Eghbali M, Blumenfeld OO, Seifter S, Buttrick PM, Leinwand LA, Robinson TF, et al. (1989). Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol, 21:103-113. - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources
- Europe PubMed Central
- PubMed Central

[1] Berk BC, Fujiwara K, Lehoux S (2007). ECM remodeling in hypertensive heart disease. J Clin Invest, 117:568-575. - PMC - PubMed

[2] Berk BC, Fujiwara K, Lehoux S (2007). ECM remodeling in hypertensive heart disease. J Clin Invest, 117:568-575. - PMC - PubMed

[3] Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI (1988). Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res, 62:757-765. - PubMed

[4] Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI (1988). Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res, 62:757-765. - PubMed

[5] Medugorac I, Jacob R (1983). Characterisation of left ventricular collagen in the rat. Cardiovasc Res, 17:15-21. - PubMed

[6] Medugorac I, Jacob R (1983). Characterisation of left ventricular collagen in the rat. Cardiovasc Res, 17:15-21. - PubMed

[7] Eghbali M, Czaja MJ, Zeydel M, Weiner FR, Zern MA, Seifter S, et al. (1988). Collagen chain mRNAs in isolated heart cells from young and adult rats. J Mol Cell Cardiol, 20:267-276. - PubMed

[8] Eghbali M, Czaja MJ, Zeydel M, Weiner FR, Zern MA, Seifter S, et al. (1988). Collagen chain mRNAs in isolated heart cells from young and adult rats. J Mol Cell Cardiol, 20:267-276. - PubMed

[9] Eghbali M, Blumenfeld OO, Seifter S, Buttrick PM, Leinwand LA, Robinson TF, et al. (1989). Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol, 21:103-113. - PubMed

[10] Eghbali M, Blumenfeld OO, Seifter S, Buttrick PM, Leinwand LA, Robinson TF, et al. (1989). Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol, 21:103-113. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Roles of Biomarkers in Myocardial Fibrosis

Affiliations

Roles of Biomarkers in Myocardial Fibrosis

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

Related information

LinkOut - more resources

Full Text Sources