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Review
. 2020;7(4):124-132.
doi: 10.1007/s40588-020-00152-6. Epub 2020 Sep 26.

Reactive Arthritis: Update

Ibtissam Bentaleb  1 , Kawther Ben Abdelghani  2 , Samira Rostom  1 , Bouchra Amine  1 , Ahmed Laatar  2 , Rachid Bahiri  1
Affiliations
Review

Reactive Arthritis: Update

Ibtissam Bentaleb et al. Curr Clin Microbiol Rep. 2020.

Abstract

Purpose of review: The aim of this paper is to provide an overview about reactive arthritis, with an update regarding pathophysiology and therapeutic approach of the disease, outlining the clinical features and diagnostic approach, based on recent literature review.

Recent findings: Reactive arthritis is considered to be part of the spectrum of the spondyloarthritis. Its epidemiology is changing worldwide due to several reasons, among them are as follows: different diagnosis approach and clinical presentations, different grades of infection, microbiome changes, etc. The understanding of pathophysiological models is challenging, but recent studies contribute to elucidate the major factors involved in the development of the disease. The management of ReA depends on the triggering agent and the phase of disease, whether it is acute or chronic.

Summary: The association between the microbiome changes and spondyloarthropathies (ReA) is becoming increasingly evident. The results regarding the biologic treatment on refectory ReA are promising.

Keywords: Chlamydia-induced reactive arthritis; HLA-B27; Reactive arthritis; Spondyloarthritis.

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Conflict of interest statement

Conflict of InterestThe authors declare that they have no conflicts of interest.

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References

    1. García-Kutzbach A, Chacón-Súchite J, García-Ferrer H, Iraheta I. Reactive arthritis: update 2018. Clin Rheumatol. 2018;37(4):869–874. - PubMed
    1. Pennisi M, Perdue J, Roulston T, Nicholas J, Schmidt E, Rolfs J. An overview of reactive arthritis. J Am Acad Physician Assist. 2019;32(7):25–28. - PubMed
    1. •• Espinoza LR, editor. Infections and the rheumatic diseases. Cham: Springer International Publishing; 2019 [cited 2020 May 9]. Available from: http://link.springer.com/10.1007/978-3-030-23311-2. This book highlight the importance of infectious agents in the etiology and pathogenesis of musculoskeletal disorders including Reactive arthritis, as well as the role they play in affecting the natural course, disease expression, progression, and clinical response to conventional and biological therapy. - DOI
    1. Manasson J, Shen N, Ferrer HRG, Ubeda C, Iraheta I, Heguy A, et al. Gut microbiota perturbations in reactive arthritis and post-infectious spondyloarthritis. Arthritis Rheumatol Hoboken NJ. 2018;70(2):242–254. - PMC - PubMed
    1. Gupta R, Misra R. Microbe-triggered arthropathies: reactive arthritis and beyond. Int J Rheum Dis. 2016;19(5):437–439. - PubMed

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