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. 2020 Sep 15:2020:7647181.
doi: 10.1155/2020/7647181. eCollection 2020.

Clinical Significance of CD147 in Children with Inflammatory Bowel Disease

Hongli Wang  1   2 , Jun Ye  3 , Ruitao Liu  2 , Guanhua Chen  2 , Junhong Zhao  2 , Ling Huang  2 , Fangying Yang  2 , Musheng Li  2 , Shunxian Zhang  2 , Jingxie  2 , Liya Xiong  2 , Huan Chen  2 , Yuxin Xu  3 , Mingmin Su  4 , Yuanwen Xie  5 , Songyu Li  6 , Fengfeng Zheng  7 , Lanlan Geng  2 , Wanfu Xu  2   8 , Sitang Gong  1   2   8
Affiliations

Clinical Significance of CD147 in Children with Inflammatory Bowel Disease

Hongli Wang et al. Biomed Res Int. .

Abstract

Background: CD147/basigin (Bsg), a transmembrane glycoprotein, activates matrix metalloproteinases and promotes inflammation.

Objective: The aim of this study is to explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD).

Results: In addition to monocytes, the clinical analysis showed that there is no significance obtained in leucocyte, neutrophil, eosinophil, basophil, and erythrocyte between IBD and controls. Immunohistochemistry analysis showed that CD147 was increased in intestinal tissue of patients with active IBD compared to that in the control group. What is more, CD147 is involved in intestinal barrier function and intestinal inflammation, which was attributed to the fact that it has an influence on MCT4 expression, a regulator of intestinal barrier function and intestinal inflammation, in HT-29 and CaCO2 cells. Most importantly, serum level of CD147 content is higher in active IBD than that in inactive IBD or healthy control, which could be a biomarker of IBD.

Conclusion: The data suggested that increased CD147 level could be a biomarker of IBD in children.

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Conflict of interest statement

The authors declared that they have no competing interests.

Figures

Figure 1
Figure 1
Clinical characteristic of patients. Statistical analysis of indicated index in patients with control (inactive stage) and active IBD.
Figure 2
Figure 2
Evaluated CD147 is increased in intestinal mucosa. (a, b) Western blotting and real-time PCR were performed to detect the effect of CD147 on MCT4 expression in IECs. Immunohistochemical analysis was employed to examine CD147 expression in the indicated group (c), and relative density of CD147 was analyzed by t-test analysis (d).
Figure 3
Figure 3
Serum CD147 level was measured in patients with IBD. (a) The blood was collected from patients in clinic, and ELISA for CD147 was measured to analyze its clinical significance. (B) The relationship was performed between DAI and serum CD147 level.
See this image and copyright information in PMC

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