Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis
- PMID: 33015412
- PMCID: PMC7524777
- DOI: 10.1016/j.jacbts.2020.06.012
Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis
Abstract
Our objectives were to determine whether autotaxin (ATX) is transported by lipoprotein(a) [Lp(a)] in human plasma and if could be used as a biomarker of calcific aortic valve stenosis (CAVS). We first found that ATX activity was higher in Lp(a) compared to low-density lipoprotein fractions in isolated fractions of 10 healthy participants. We developed a specific assay to measure ATX-Lp(a) in 88 patients with CAVS and 144 controls without CAVS. In a multivariable model corrected for CAVS risk factors, ATX-Lp(a) was associated with CAVS (p = 0.003). We concluded that ATX is preferentially transported by Lp(a) and might represent a novel biomarker for CAVS.
Keywords: ALR, adiponectin-to-leptin ratio; ATX, autotaxin; ATX-apo(a), ATX carried by Lp(a); ATX-apoB, ATX carried by apoB-containing lipoproteins; BMI, body mass index; CAD, coronary artery disease; CAVS, calcific aortic valve stenosis; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Lp(a), lipoprotein(a); LysoPA, lysophosphatidic acid; LysoPC, lysophosphatidylcholine; OxPLs, oxidized phospholipids; apo(a), apolipoprotein(a); apoB, apolipoprotein B; autotaxin; calcific aortic valve stenosis; lipoprotein(a); low-density lipoproteins; obesity.
© 2020 The Authors.
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Comment in
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An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease.JACC Basic Transl Sci. 2020 Sep 28;5(9):898-900. doi: 10.1016/j.jacbts.2020.04.016. eCollection 2020 Sep. JACC Basic Transl Sci. 2020. PMID: 33016951 Free PMC article.
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