Recent insights into Histone Acetyltransferase-1: biological function and involvement in pathogenesis

Abstract

Acetylation of histone and non-histone proteins is a post-translational modification mostly associated with activation of gene transcription. The first histone acetyltransferase (HAT) identified as modifying newly synthesized histone H4 in yeast was a type B HAT named HAT1. Although it was the first HAT to be discovered, HAT1 remains one of the most poorly studied enzymes in its class. In addition to its well-established role in the cytoplasm, recent findings have revealed new and intriguing aspects of the function of HAT1 in the nucleus. Several studies have described its involvement in regulating different pathways associated with a wide range of diseases, including cancer. This review focuses on our current understanding of HAT1, highlighting its importance in regulating chromatin replication and gene expression. This previously unknown role for HAT1 opens up novel scenarios in which further studies will be required to better understand its function.

Keywords: HAT1 inhibitors; Histone Acetyltransferase-1; acetylation; epigenetics; histones H3-H4.

Figure 1.

Representative model of the mechanism by which HAT1/KAT1 cytoplasmic complexes shuttle into the nucleus

Figure 2.

Overview of the HAT1/KAT1 biological functions