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. 2020 Nov 7;56(86):13105-13108.
doi: 10.1039/d0cc05121g. Epub 2020 Oct 5.

Mobility of Lewis acids within the secondary coordination sphere: toward a model for cooperative substrate binding

John J Kiernicki  1 , Emily E Norwine, Myles A Lovasz, Matthias Zeller, Nathaniel K Szymczak
Affiliations

Mobility of Lewis acids within the secondary coordination sphere: toward a model for cooperative substrate binding

John J Kiernicki et al. Chem Commun (Camb). .

Abstract

Distance dependence of appended Lewis acids in N2H4 binding and deprotonation was evaluated within a series of zinc complexes. Variation of spacer-length to a tethered trialkylborane Lewis acid revealed distinct preferences for binding and stabilization of the resulting deprotonated N2H3- unit.

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Conflict of interest statement

Conflicts of interest

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1
Left: Conceptual design. Right: specific substrates investigated in this study and their potential binding modes.
Fig. 2
Fig. 2
A) Synthesis of complexes A. B) Molecular structures (50% probability ellipsoids) of A-2 and A-4 as well as their vinyl and butenyl precursors, respectively. H-atoms not attached to alkenyl moieties are omitted for clarity.
Fig.3
Fig.3
A) Reversible formation of C from B. B) Molecular structures (50% probability ellipsoids, only H-atoms attached to heteroatoms are displayed). B-3 is previously reported.
Fig. 4
Fig. 4
A) Top: Dynamic solution behaviour of complexes C. Left: reversible deprotonation of C-3 to form D-3 and molecular structure of D-3 (50% probability ellipsoids, only H-atoms attached to heteroatoms displayed). B) Calculated pKa values.
See this image and copyright information in PMC

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