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Comment
. 2020 Nov;98(10):802-804.
doi: 10.1111/imcb.12403. Epub 2020 Oct 5.

NKG7 - regulating endosomal pathways?

Iona S Schuster  1   2 , Christopher E Andoniou  1   2
Affiliations
Comment

NKG7 - regulating endosomal pathways?

Iona S Schuster et al. Immunol Cell Biol. 2020 Nov.

Abstract

Ng et al. have identified NKG7 as a regulator of inflammation in response to diverse immunological challenges. While NKG7 was required for the degranulation of cytotoxic cells, additional defects including reduced expansion and trafficking of CD8 T cells, and altered antigen presentation, were noted in NKG7-deficient mice. The precise mechanism by which NKG7 mediates its effects has not been resolved but may involve regulation of endosomal vesicle trafficking.

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Comment on

  • The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
    Ng SS, De Labastida Rivera F, Yan J, Corvino D, Das I, Zhang P, Kuns R, Chauhan SB, Hou J, Li XY, Frame TCM, McEnroe BA, Moore E, Na J, Engel JA, Soon MSF, Singh B, Kueh AJ, Herold MJ, Montes de Oca M, Singh SS, Bunn PT, Aguilera AR, Casey M, Braun M, Ghazanfari N, Wani S, Wang Y, Amante FH, Edwards CL, Haque A, Dougall WC, Singh OP, Baxter AG, Teng MWL, Loukas A, Daly NL, Cloonan N, Degli-Esposti MA, Uzonna J, Heath WR, Bald T, Tey SK, Nakamura K, Hill GR, Kumar R, Sundar S, Smyth MJ, Engwerda CR. Ng SS, et al. Nat Immunol. 2020 Oct;21(10):1205-1218. doi: 10.1038/s41590-020-0758-6. Epub 2020 Aug 24. Nat Immunol. 2020. PMID: 32839608 Free PMC article.

References

REFERENCES

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