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Review
. 2020 Oct 30;40(10):BSR20201105.
doi: 10.1042/BSR20201105.

The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus

Jieyuan Cui  1   2 , Xiaolin Zhang  3 , Cheng Guo  2 , Lin Zhang  2
Affiliations
Review

The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus

Jieyuan Cui et al. Biosci Rep. .

Abstract

Objectives: To evaluate the effects of the single-nucleotide polymorphism (SNP) rs1800795 in interieukin-6 (IL-6) gene on diabetic microvascular complications of Type 2 diabetes mellitus (T2DM), using statistical meta-analysis.

Methods: Literature pertaining to the relationship between the SNP rs1800795 and microvascular complications of T2DM including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy and foot disease was retrieved from PubMed, Web of Science Knowledge and SinoMed databases. Original information was analyzed using Stata 12.0, including meta-analysis statistics, test for heterogeneity, evaluation of publication bias and sensitivity. Subgroup analysis was conducted to assess the effect of specific factors on the corresponding results.

Results: In total, 14 eligible articles were obtained. The SNP rs1800795 in IL-6 gene is not correlated with risk of microvascular complications in T2DM. Among the original literature, a genetic model (OR = 1.071, 95% CI: 0.681-1.685, P=0.767), an allelic genetic model (OR = 1.010, 95% CI: 0.959-1.063, P=0.703), a heterozygote genetic model (OR = 1.107, 95% CI: 0.916-1.339, P=0.292), a dominant genetic model (OR = 1.108, 95% CI: 0.885-1.387, P=0.372), and a recessive genetic model (OR = 0.978, 95% CI: 0.646-1.478, P=0.917) were included respectively. In the subgroup analysis by types of diabetic microvascular complications, we found no correlation between the SNP rs1000795 polymorphism and complications of T2DM in either the homozygote genetic model or the allelic genetic model (P<0.05).

Conclusion: Our results demonstrate that rs1800795 polymorphism in IL-6 gene is not correlated with the susceptibility of microvascular complications of T2DM.

Keywords: Diabetic microvascular complications; Gene polymorphism; Interleukin-6 gene; Type 2 diabetes mellitus; rs1800795.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Study selection flowchart
Figure 2
Figure 2. Forest plot for meta-analysis of association between IL-6 -174G/C polymorphism with risk of complications in Type 2 diabetes in subgroup analysis
Begg’s funnel plot showing the publication bias and results of sensitivity analysis showing by measurement tool of leave one out in subgroup analysis.
Figure 2
Figure 2. Forest plot for meta-analysis of association between IL-6 -174G/C polymorphism with risk of complications in Type 2 diabetes in subgroup analysis
Begg’s funnel plot showing the publication bias and results of sensitivity analysis showing by measurement tool of leave one out in subgroup analysis.
See this image and copyright information in PMC

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