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. 2020 Oct;17(10):976-986.
doi: 10.30773/pi.2020.0212. Epub 2020 Oct 6.

Hair Cortisol as a Marker of Intergenerational Heritage of War? A Study of Veterans and Their Offspring

Ivone Castro-Vale  1   2 , Elisabeth F C van Rossum  3 , Sabine M Staufenbiel  3 , Milton Severo  4 , Rui Mota-Cardoso  1 , Davide Carvalho  2   5
Affiliations

Hair Cortisol as a Marker of Intergenerational Heritage of War? A Study of Veterans and Their Offspring

Ivone Castro-Vale et al. Psychiatry Investig. 2020 Oct.

Abstract

Objective: Posttraumatic stress disorder (PTSD) has been associated with lower circulating cortisol levels in specific subgroups, which have also been found in the offspring of people with PTSD. The analysis of hair cortisol concentrations (HCC) is a recent methodology which is used to assess long-term systemic cortisol levels. We aimed to study veterans with war-related lifetime PTSD and their respective offspring with regards to HCC. We also studied the influence of lifetime major depressive disorder (MDD), war experiences, and childhood adversities on HCC in these groups.

Methods: 31 male veterans with PTSD and 28 without PTSD and 69 adult offspring were studied. HCC were quantified by liquid chromatography tandem-mass spectrometry.

Results: No differences in HCC were found between veterans with and without PTSD, or between their respective offspring. Veterans without MDD showed a positive association between total war exposure and HCC. Veterans reporting more frequent childhood physical abuse had lower HCC. Veterans-with-PTSD's offspring with MDD had increased HCC compared to offspring without MDD. Offspring's exposure to more frequent childhood physical abuse was negatively associated with HCC in those without MDD.

Conclusion: HCC did not appear to constitute a marker of intergenerational heritage of war-related PTSD, except in the case of veteranswith-PTSD's offspring with MDD. Our data suggest that HCC is a marker of adult reported childhood physical abuse.

Keywords: Childhood adversities; Hair cortisol; Intergenerational transmission; Major depressive disorder; Posttraumatic stress disorder; War veterans.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

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References

    1. Daskalakis NP, Lehrner A, Yehuda R. Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment. Endocrinol Metab Clin North Am. 2013;42:503–513. - PubMed
    1. Morris MC, Compas BE, Garber J. Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis. Clin Psychol Rev. 2012;32:301–315. - PMC - PubMed
    1. Lightman SL, Conway-Campbell BL. The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration. Nat Rev Neurosci. 2010;11:710–718. - PubMed
    1. Manenschijn L, Koper JW, Lamberts SW, van Rossum EF. Evaluation of a method to measure long term cortisol levels. Steroids. 2011;76:1032–1036. - PubMed
    1. Pragst F, Balikova MA. State of the art in hair analysis for detection of drug and alcohol abuse. Clin Chim Acta. 2006;370:17–49. - PubMed

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