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. 1977 Jun 15;33(6):769-71.
doi: 10.1007/BF01944182.

Activation of complement by trypanosomes

K Nielsen, J Sheppard

Activation of complement by trypanosomes

K Nielsen et al. Experientia. .

Abstract

Factors exhibiting anti-complementary activity released from trypanosomes after incubation at 20 degrees C were described. The active material was shown to consume the first component of bovine complement. While the anti-complementary factor(s) from T. lewisi could activate bovine, human and guinea pig complement, the factor(s) from T. congolense was observed to activate bovine complement, but not guinea pig and only slightly human complement. The roles of complement activating factor(s) of trypanosomes in the pathology of the disease are discussed.

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References

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