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Review
. 2020 Oct 4;9(10):2238.
doi: 10.3390/cells9102238.

The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

Artem Nedoluzhko  1   2 , Natalia Gruzdeva  3 , Fedor Sharko  3   4 , Sergey Rastorguev  3 , Natalia Zakharova  2 , Georgy Kostyuk  2 , Vadim Ushakov  2   5
Affiliations
Review

The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

Artem Nedoluzhko et al. Cells. .

Abstract

Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation. Circular RNAs can affect microRNA functionality, interact with RNA-binding proteins (RBPs), translate proteins by themselves, and directly or indirectly modulate gene expression during different cellular processes. The affected expression of circRNAs, as well as their targets, can trigger a cascade of events in the genetic regulatory network causing pathological conditions. Recent studies have shown that altered circular RNA expression patterns could be used as biomarkers in psychiatric diseases, including schizophrenia (SZ); moreover, circular RNAs together with other cell molecules could provide new insight into mechanisms of this disorder. In this review, we focus on the role of circular RNAs in the pathogenesis of SZ and analyze their biomarker and therapeutic potential in this disorder.

Keywords: RBPs; biomarkers; circRNAs; circular RNAs; expression; microRNAs; schizophrenia; sponge; therapy.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
The main regulatory functions of circular RNAs in the cell. (A) Interacting with RNA-binding proteins; (B) Moderating microRNA expression, acting like microRNA sponges; (C) Interacting with RNA polymerase II and regulating gene expression; (D) Peptide/protein translation. Created with BioRender.com.
Figure 2
Figure 2
The biomarker and therapeutic potential of circular RNAs in schizophrenia. (A) Potential molecular markers in schizophrenia. (B) Circular RNAs as a potential player in schizophrenia therapy. Created with BioRender.com.
See this image and copyright information in PMC

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