Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec;44(12):e13493.
doi: 10.1111/jfbc.13493. Epub 2020 Oct 5.

The effects of royal jelly and tocotrienol-rich fraction on impaired glycemic control and inflammation through irisin in obese rats

Pardis Irandoost  1 , Naimeh Mesri Alamdari  1 , Atoosa Saidpour  2 , Farzad Shidfar  3   4 , Neda Roshanravan  5 , Mohammad Asghari Jafarabadi  6   7 , Farnaz Farsi  1   4 , Nazanin Asghari Hanjani  1 , Mohammadreza Vafa  3
Affiliations

The effects of royal jelly and tocotrienol-rich fraction on impaired glycemic control and inflammation through irisin in obese rats

Pardis Irandoost et al. J Food Biochem. 2020 Dec.

Abstract

The effects of royal jelly (RJ) and tocotrienol-rich fraction (TRF) on obesity-induced glucose intolerance and inflammation were assessed in the current study. Regarding irisin as an important adipomyokine that attenuates obesity-induced disorders, we evaluated whether RJ and TRF could exert their metabolism regulatory effects through irisin. Obese rats were fed a high-fat diet (HFD) with or without supplementation of RJ, TRF, or both, for 8 weeks. At the end of the intervention, weight, irisin, glycemic, and inflammatory indices were measured. The weight of the rats did not remarkably reduce in any of the groups. Glucose homeostasis and inflammation were improved when we added RJ and TRF to HFD. RJ elevated irisin concentration, but the effect of TRF on irisin was not noticeable. Our results indicated that, despite the lack of significant weight loss, RJ and TRF promoted healthy obesity. This improvement was mediated by irisin in RJ consuming rats. PRACTICAL APPLICATIONS: Obesity is a public health concern associated with several chronic disorders. The beneficial effects of irisin on obesity-related disorders are well-established. It is the first study assessing the effect of RJ and TRF as functional foods, with pharmacological and nutritional activities on obesity complications, through irisin mediation. Our study demonstrated that RJ exerts its metabolic regulatory effects by irisin as a mediator. Our investigation makes a remarkable contribution to the literature, because it suggests a new mechanism for the anti-obesity properties of RJ and TRF.

Keywords: glucose intolerance; inflammation; irisin; obesity-induced disorders; royal jelly; tocotrienol-rich fraction.

PubMed Disclaimer

References

REFERENCES

    1. Allen, L., Ramalingam, L., Menikdiwela, K., Scoggin, S., Shen, C.-L., Tomison, M. D., Kaur, G., Dufour, J. M., Chung, E., Kalupahana, N. S., & Moustaid-Moussa, N. (2017). Effects of delta-tocotrienol on obesity-related adipocyte hypertrophy, inflammation and hepatic steatosis in high-fat-fed mice. The Journal of Nutritional Biochemistry, 48, 128-137. https://doi.org/10.1016/j.jnutbio.2017.07.003
    1. Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51(6), 1173. https://doi.org/10.1037/0022-3514.51.6.1173
    1. Candiracci, M., Justo, M. L., Castaño, A., Rodriguez-Rodriguez, R., & Herrera, M. D. (2014). Rice bran enzymatic extract-supplemented diets modulate adipose tissue inflammation markers in Zucker rats. Nutrition, 30(4), 466-472. https://doi.org/10.1016/j.nut.2013.09.016
    1. Che, H.-L., Kanthimathi, M. S., Loganathan, R., Yuen, K. H., Tan, A. T. B., Selvaduray, K. R., Nesaretnam, K., & Teng, K.-T. (2017). Acute effects of a single dose of tocotrienols on insulinemic and inflammatory responses in metabolic syndrome subjects after a high-fat challenge. European Journal of Clinical Nutrition, 71(1), 107-114. https://doi.org/10.1038/ejcn.2016.200
    1. Cheng, H. S., Ton, S. H., Tan, J. B. L., & Abdul Kadir, K. (2017). The ameliorative effects of a tocotrienol-rich fraction on the AGE-RAGE axis and hypertension in high-fat-diet-fed rats with metabolic syndrome. Nutrients, 9(9), 984. https://doi.org/10.3390/nu9090984

Publication types

LinkOut - more resources