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. 2021 Jan;40(1):26-31.
doi: 10.1097/INF.0000000000002908.

Psychiatric Disabilities and Other Long-term Consequences of Childhood Bacterial Meningitis

Urban Johansson Kostenniemi  1   2 , Aleksander Bazan  1 , Linda Karlsson  2 , Sven-Arne Silfverdal  1
Affiliations

Psychiatric Disabilities and Other Long-term Consequences of Childhood Bacterial Meningitis

Urban Johansson Kostenniemi et al. Pediatr Infect Dis J. 2021 Jan.

Abstract

Background: Bacterial meningitis is known to cause hearing impairments and neurologic deficits; however, less is known regarding psychiatric disabilities. In this study, we assessed psychiatric disabilities and other long-term consequences of childhood bacterial meningitis.

Methods: From a previously validated dataset, we selected children having had bacterial meningitis. We then reviewed medical records and child health records from discharge onwards to identify disabilities. We calculated the occurrence of disabilities with a 95% confidence interval (CI), and we used a χ test to assess possible individual risk factors associated with occurrence of disabilities.

Results: Of the 80 children included in this study, permanent disabilities not attributed to preexisting diseases were noted in 56% (CI: 45-67) during the mean observation period of 19 years and 2 months. Psychiatric disease was diagnosed in 30% (CI: 21-41), and another 5% (CI: 2-13) were under ongoing investigations for symptoms of psychiatric disease. Hearing impairments affected at least 30% (CI: 20-40), and neurologic deficits affected at least 23% (CI: 15-34). While other disabilities were often detected within the first year, psychiatric disabilities were detected after a mean time period of 14 years (CI: 11:1-16:11). Although some associations were noted, no individual risk factor was able to predict the occurrence of disabilities.

Conclusions: Psychiatric disabilities affect more than one-third of survivors and are among the most common long-term consequence of childhood bacterial meningitis. Late discovery and predictive difficulties call for a revision of current guidelines to include a specific long-term strategy for detecting psychiatric disabilities.

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