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. 2021 Mar;27(3):489-490.

doi: 10.1016/j.cmi.2020.09.049. Epub 2020 Oct 3.

SARS-CoV-2 ACE-receptor detection in the placenta throughout pregnancy

Carole Gengler¹, Estelle Dubruc¹, Guillaume Favre², Gilbert Greub³, Laurence de Leval¹, David Baud⁴

Affiliations

Affiliations

¹ Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
² Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
³ Center for Research on Intracellular Bacteria, Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, CH-1011, Lausanne, Switzerland.
⁴ Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: david.baud@chuv.ch.

PMID: 33022363
PMCID: PMC7532787
DOI: 10.1016/j.cmi.2020.09.049

SARS-CoV-2 ACE-receptor detection in the placenta throughout pregnancy

Carole Gengler et al. Clin Microbiol Infect. 2021 Mar.

. 2021 Mar;27(3):489-490.

doi: 10.1016/j.cmi.2020.09.049. Epub 2020 Oct 3.

Authors

Carole Gengler¹, Estelle Dubruc¹, Guillaume Favre², Gilbert Greub³, Laurence de Leval¹, David Baud⁴

Affiliations

¹ Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
² Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
³ Center for Research on Intracellular Bacteria, Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, CH-1011, Lausanne, Switzerland.
⁴ Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: david.baud@chuv.ch.

PMID: 33022363
PMCID: PMC7532787
DOI: 10.1016/j.cmi.2020.09.049

No abstract available

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Figures

Fig. 1 — Fig. 1
Diffuse membranous staining of villous cytotrophoblast and syncytiotrophoblast cells (arrows) with monoclonal Anti-ACE2 antibody (clone CL4035), dilution 1/1000 in a COVID-19 positive mother, 19 weeks of amenorrhea.

See this image and copyright information in PMC

References

1. Bahadur G., Homburg R., Yoong W., Singh C., Bhat M., Kotabagi P. Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission. JBRA Assist Reprod. 2020;24:351–357. - PMC - PubMed
1. Schwartz D.A., Morotti D., Beigi B., Moshfegh F., Zafaranloo N., Patane L. Confirming vertical fetal infection with COVID-19: neonatal and pathology criteria for early onset and transplacental transmission of SARS-CoV-2 from infected pregnant mothers. Arch Pathol Lab Med. 2020 doi: 10.5858/arpa.2020-0442-SA. - DOI - PubMed
1. Baud D., Nielsen-Saines K., Qi X., Musso D., Pomar L., Favre G. Authors' reply. Lancet Infect Dis. 2020;20:775–776. - PMC - PubMed
1. Kotlyar A., Grechukhina O., Chen A., Popkhadze S., Grimshaw A., Tal O. Vertical transmission of COVID-19: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020 - PMC - PubMed
1. Vivanti A.J., Vauloup-Fellous C., Prevot S., Zupan V., Suffee C., Do Cao J. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11:3572. - PMC - PubMed

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