Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Oct 3;12(10):1124.
doi: 10.3390/v12101124.

The Role of Phosphatidylinositol Phosphate Kinases during Viral Infection

Anne Beziau  1 , Denys Brand  1   2 , Eric Piver  1   3
Affiliations
Review

The Role of Phosphatidylinositol Phosphate Kinases during Viral Infection

Anne Beziau et al. Viruses. .

Abstract

Phosphoinositides account for only a small proportion of cellular phospholipids, but have long been known to play an important role in diverse cellular processes, such as cell signaling, the establishment of organelle identity, and the regulation of cytoskeleton and membrane dynamics. As expected, given their pleiotropic regulatory functions, they have key functions in viral replication. The spatial restriction and steady-state levels of each phosphoinositide depend primarily on the concerted action of specific phosphoinositide kinases and phosphatases. This review focuses on a number of remarkable examples of viral strategies involving phosphoinositide kinases to ensure effective viral replication.

Keywords: phosphatases; phosphatidylinositol (PI); phosphatidylinositol phosphate kinases (PIPK); viral replication.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Interconversion of phosphoinositides mediated by cellular enzymes. The interconversion reactions for the controlled production of the seven types of phosphoinositides (PPIns) are shown. These reactions involve different phosphatidylinositol kinases (blue arrows) and phosphatidylinositol phosphatases (red arrows).
Figure 2
Figure 2
Schematic diagram of the subcellular distribution of phosphoinositides and sites targeted by positive-strand RNA viruses. Non-exhaustive representation of the subcellular distribution of the seven forms of phosphoinositides. Several cellular processes in which PPIns are also used are shown. The membranes of subcellular compartments are stained according to the types of PPIns predominantly present. The location of the kinases is indicated by their position, as are the sites targeted by the different RNA (+) viruses. (EBOV, Ebola virus; PV, poliovirus; SARS-CoV (1 and 2), severe acute respiratory syndrome coronavirus; MERS-CoV, Middle East respiratory syndrome-related coronavirus; HIV-1, human immunodeficiency virus; HCV, hepatitis C virus).
See this image and copyright information in PMC

References

    1. Balla T. Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation. Physiol. Rev. 2013;93:1019–1137. doi: 10.1152/physrev.00028.2012. - DOI - PMC - PubMed
    1. Hu J., Yuan Q., Kang X., Qin Y., Li L., Ha Y., Wu D. Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled. Nat. Commun. 2015;6:8205. doi: 10.1038/ncomms9205. - DOI - PMC - PubMed
    1. Lacalle R.A., De Karam J.C., Martínez-Muñoz L., Artetxe I., Peregil R.M., Sot J., Rojas A.M., Goñi F.M., Mellado M., Mañes S. Type I phosphatidylinositol 4-phosphate 5-kinase homoand heterodimerization determines its membrane localization and activity. FASEB J. 2015;29:2371–2385. doi: 10.1096/fj.14-264606. - DOI - PubMed
    1. Antonsson B. Phosphatidylinositol synthase from mammalian tissues. Biochim. et Biophys. Acta (BBA)-Lipids Lipid Metab. 1997;1348:179–186. doi: 10.1016/S0005-2760(97)00105-7. - DOI - PubMed
    1. Di Paolo G., De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature. 2006;443:651–657. doi: 10.1038/nature05185. - DOI - PubMed

MeSH terms

Substances