Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Oct 2;21(19):7292.
doi: 10.3390/ijms21197292.

The Progression of Hemophilic Arthropathy: The Role of Biomarkers

Gianluigi Pasta  1 , Salvatore Annunziata  1 , Alberto Polizzi  1 , Laura Caliogna  1 , Eugenio Jannelli  1 , Alessandro Minen  1 , Mario Mosconi  1 , Francesco Benazzo  1 , Matteo Nicola Dario Di Minno  2
Affiliations
Review

The Progression of Hemophilic Arthropathy: The Role of Biomarkers

Gianluigi Pasta et al. Int J Mol Sci. .

Abstract

Background: Hemophilia A and B are X-linked congenital bleeding disorders characterized by recurrent hemarthroses leading to specific changes in the synovium and cartilage, which finally result in the destruction of the joint: this process is called hemophilic arthropathy (HA). This review highlights the most prominent molecular biomarkers found in the literature to discuss their potential use in the clinical practice to monitor bleeding, to assess the progression of the HA and the effectiveness of treatments.

Methods: A review of the literature was performed on PubMed and Embase, from 3 to 7 August 2020. Study selection and data extraction were achieved independently by two authors and the following inclusion criteria were determined a priori: English language, available full text and articles published in peer-reviewed journal. In addition, further articles were identified by checking the bibliography of relevant articles and searching for the studies cited in all the articles examined.

Results: Eligible studies obtained at the end of the search and screen process were seventy-three (73).

Conclusions: Despite the surge of interest in the clinical use of biomarkers, current literature underlines the lack of their standardization and their potential use in the clinical practice preserving the role of physical examination and imaging in early diagnosis.

Keywords: arthropathy; biomarkers; hemophilia.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mannucci P.M., Tuddenham E.G. The hemophilias—From royal genes to gene therapy. N. Engl. J. Med. 2001;344:1773–1779. doi: 10.1056/NEJM200106073442307. - DOI - PubMed
    1. Van Vulpen L.F.D., Holstein K., Martinoli C. Joint disease in haemophilia: Pathophysiology, pain and imaging. Haemophilia. 2018;24:44–49. doi: 10.1111/hae.13449. - DOI - PubMed
    1. Van Vulpen L.F.D., Roosendaal G., Schutgens R.E.G., Lafeber F.P.J.G. Chapter 119 - Hemophilic Arthropathy. In: Firestein G.S., Budd R.C., Gabriel S.E., McInnes I.B., O’Dell J.R., editors. Kelley and Firestein’s Textbook of Rheumatology. 10th ed. 2017. pp. 2007–2017.
    1. Melchiorre D., Manetti M., Matucci-Cerinic M. Pathophysiology of Hemophilic Arthropathy. J. Clin. Med. 2017;6:63. doi: 10.3390/jcm6070063. - DOI - PMC - PubMed
    1. Pulles A.E., Mastbergen S.C., Schutgens R.E.G., Lafeber F.P.J.G., van Vulpen L.F.D. Pathophysiology of hemophilic arthropathy and potential targets for therapy. Pharmacol. Res. 2017;115:192–199. doi: 10.1016/j.phrs.2016.11.032. - DOI - PubMed