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. 2020 Oct 6;13(1):467.
doi: 10.1186/s13104-020-05318-5.

Unidentified dengue serotypes in DENV positive samples and detection of other pathogens responsible for an acute febrile illness outbreak 2016 in Cajamarca, Peru

Juana Del Valle-Mendoza  1   2 , Fernando Vasquez-Achaya  3 , Miguel Angel Aguilar-Luis  3   4 , Johanna Martins-Luna  3   4 , Jorge Bazán-Mayra  5 , Victor Zavaleta-Gavidia  5 , Wilmer Silva-Caso  3   4 , Hugo Carrillo-Ng  3   4 , Yordi Tarazona-Castro  4   6 , Ronald Aquino-Ortega  3   4 , Luis J Del Valle  7
Affiliations

Unidentified dengue serotypes in DENV positive samples and detection of other pathogens responsible for an acute febrile illness outbreak 2016 in Cajamarca, Peru

Juana Del Valle-Mendoza et al. BMC Res Notes. .

Abstract

Objective: To describe the prevalence of dengue virus serotypes, as well as other viral and bacterial pathogens that cause acute febrile illness during an outbreak in Cajamarca in 2016.

Results: Dengue virus (DENV) was the most frequent etiologic agent detected in 25.8% of samples (32/124), followed by Rickettsia spp. in 8.1% (10/124), Zika virus in 4.8% (6/124), Chikungunya virus 2.4% (3/124) and Bartonella bacilliformis 1.6% (2/124) cases. No positive cases were detected of Oropouche virus and Leptospira spp. DENV serotypes identification was only achieved in 23% of the total positive for DENV, two samples for DENV-2 and four samples for DENV-4. During the 2016 outbreak in Cajamarca-Peru, it was observed that in a large percentage of positive samples for DENV, the infecting serotype could not be determined by conventional detection assays. This represents a problem for the national surveillance system and for public health due to its epidemiological and clinical implications. Other viral and bacterial pathogens responsible for acute febrile syndrome were less frequently identified.

Keywords: Arbovirus; Chikungunya; Dengue; PCR; Peru; Zika.

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there are no conflicts of interest or funding related to this study

Figures

Fig. 1
Fig. 1
Arbovirus infection geographic distribution in Cajamarca between February to June 2016
See this image and copyright information in PMC

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References

    1. Robinson ML, Manabe YC. Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape. Am J Trop Med Hyg. 2017;96(6):1285–1295. doi: 10.4269/ajtmh.16-0667. - DOI - PMC - PubMed
    1. Crump J, Gove S, Parry C. Management of adolescents and adults with febrile illness in resource limited areas. BMJ. 2011;343:d4847–d4847. doi: 10.1136/bmj.d4847. - DOI - PMC - PubMed
    1. Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases. Nature. 2004;430(6996):242–9. doi: 10.1038/nature02759. - DOI - PMC - PubMed
    1. Alva-Urcia C, Aguilar-Luis MA, Palomares-Reyes C, Silva-Caso W, Suarez-Ognio L, Weilg P, Manrique C, et al. Emerging and reemerging arboviruses: a new threat in Eastern Peru. PLoS ONE. 2017;12(11):e0187897. doi: 10.1371/journal.pone.0187897. - DOI - PMC - PubMed
    1. Shepard DS, Undurraga EA, Betancourt-Cravioto M, Guzmán MG, Halstead SB, Harris E. Approaches to refining estimates of global burden and economics of dengue. PLoS Negl Trop Dis. 2014;8(11):e3306. doi: 10.1371/journal.pntd.0003306. - DOI - PMC - PubMed