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Comment
. 2020 Oct 6;5(1):224.
doi: 10.1038/s41392-020-00338-w.

SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity

Rory D de Vries  1
Affiliations
Comment

SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity

Rory D de Vries. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Pre-existing cross-reactive T-cell immunity could impact COVID-19 disease severity. Mateus et al. show the presence of pre-existing T-cell immunity in pre-pandemic donors (donor a–d), induced by one or multiple of the seasonal HCoVs (left part of figure). It is still unclear how pre-existing immunity impacts disease severity (or outcome) after SARS-CoV-2 exposure (right part of the figure). Different pre-exposure history could lead to different cross-reactive T-cell responses and different disease severity
See this image and copyright information in PMC

Comment on

  • Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans.
    Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez SI, Dan JM, Burger ZC, Rawlings SA, Smith DM, Phillips E, Mallal S, Lammers M, Rubiro P, Quiambao L, Sutherland A, Yu ED, da Silva Antunes R, Greenbaum J, Frazier A, Markmann AJ, Premkumar L, de Silva A, Peters B, Crotty S, Sette A, Weiskopf D. Mateus J, et al. Science. 2020 Oct 2;370(6512):89-94. doi: 10.1126/science.abd3871. Epub 2020 Aug 4. Science. 2020. PMID: 32753554 Free PMC article.

References

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