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Comment
. 2020 Dec;17(12):759.
doi: 10.1038/s41569-020-00464-6.

Complexity and plasticity of cardiac cellular composition

Gregory B Lim  1
Affiliations
Comment

Complexity and plasticity of cardiac cellular composition

Gregory B Lim. Nat Rev Cardiol. 2020 Dec.

Abstract

The cellular composition of the heart is highly heterogeneous, plastic and sex-specific. These findings have important implications for understanding the functional specialization of the heart and also highlight the importance of considering biological sex in preclinical studies.

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Comment on

  • Cardiac cellularity is dependent upon biological sex and is regulated by gonadal hormones.
    Squiers GT, McLellan MA, Ilinykh A, Branca J, Rosenthal NA, Pinto AR. Squiers GT, et al. Cardiovasc Res. 2021 Aug 29;117(10):2252-2262. doi: 10.1093/cvr/cvaa265. Cardiovasc Res. 2021. PMID: 32941598 Free PMC article.
  • Cells of the adult human heart.
    Litviňuková M, Talavera-López C, Maatz H, Reichart D, Worth CL, Lindberg EL, Kanda M, Polanski K, Heinig M, Lee M, Nadelmann ER, Roberts K, Tuck L, Fasouli ES, DeLaughter DM, McDonough B, Wakimoto H, Gorham JM, Samari S, Mahbubani KT, Saeb-Parsy K, Patone G, Boyle JJ, Zhang H, Zhang H, Viveiros A, Oudit GY, Bayraktar OA, Seidman JG, Seidman CE, Noseda M, Hubner N, Teichmann SA. Litviňuková M, et al. Nature. 2020 Dec;588(7838):466-472. doi: 10.1038/s41586-020-2797-4. Epub 2020 Sep 24. Nature. 2020. PMID: 32971526 Free PMC article.

References

    1. Litviňuková M, et al. Cells of the adult human heart. Nature. 2020 doi: 10.1038/s41586-020-2797-4. - DOI - PMC - PubMed
    1. Squiers GT, et al. Cardiac cellularity is dependent upon biological sex and is regulated by gonadal hormones. Cardiovasc. Res. 2020 doi: 10.1093/cvr/cvaa265. - DOI - PMC - PubMed