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. 2021 Jan;36(1):145-151.
doi: 10.1007/s11011-020-00625-z. Epub 2020 Oct 6.

Mood disorders are associated with the reduction of brain derived neurotrophic factor in the hypocampus in rats submitted to the hipercaloric diet

Rafael Tamborena Malheiros  1 , Helena Oliveira Delgado  2 , Daniel Tassinari Felber  1 , Scheila Iria Kraus  3   4 , Adair Roberto Soares Dos Santos  3   4 , Vanusa Manfredini  1 , Morgana Duarte da Silva  5   6
Affiliations

Mood disorders are associated with the reduction of brain derived neurotrophic factor in the hypocampus in rats submitted to the hipercaloric diet

Rafael Tamborena Malheiros et al. Metab Brain Dis. 2021 Jan.

Abstract

Adipose tissue accumulation, resulting from the consumption of hypercaloric foods, can cause a dysfunction of the endocrine system. Such endocrine changes can influence the expression of various neurochemicals including brain-derived neurotrophic factor (BDNF) - associated with cognitive and emotional problems. Here, we investigated the effects of a hypercaloric diet on depression- and anxiety-like behaviors in young rats along with concomitant changes in BDNF expression levels in the hippocampus. Eight week-old Wistar rats (n = 20) were divided in: control diet (CD) group which received industrial food (n = 8) and hypercaloric diet (HD) group which received animal fat and soybean oil (n = 12). After 45 days on the diet, the animals were evaluated: body weight and blood biochemical analisys. Changes in mood disposition were evaluated using forced swim test and the elevated plus-maze, whereas hippocampal BDNF expression levels were quantified by ELISA. After 45 weeks, the CD group showed a significant increase in body weight relative to the HD group. However, the HD rats had a body fat percentage and exhibited increased level of the biochemical markers. Furthermore, the animals in the HD group presented increased immobility time in the forced swimming test, as well as reduced response to plus-maze test suggesting a depression- and anxiety-like emotional state. In addition, the HD group also showed lower BDNF expression levels in the hippocampus. This study demonstrates that a hypercaloric diet induced increase in adipose tissue concentration in young rats was associated with reduced hippocampal BDNF expression and resulted in an increase in depression- and anxiety-like behaviors. Graphical abstract.

Keywords: Anxiety; Biochemical markers; Brain-derived neurotrophic factor (BDNF); Depression; Diet high-fat; Hippocampus.

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References

    1. Akbaraly TN, Brunner EJ, Ferrie JE, Marmot MG, Kivimaki M, Singh-Manoux A (2009) Dietary pattern and depressive symptoms in middle age. Br J Psychiatry 195(5):408–413. https://doi.org/10.1192/bjp.bp.108.058925 - DOI - PubMed - PMC
    1. Ambrósio G, Kaufmann FN, Manosso L, Platt N, Ghisleni G, Rodrigues ALS, Rieger DK, Kaster MP (2018) Depression and peripheral inflammatory profile of patients with obesity. Psychoneuroendocrinology. 91:132–141. https://doi.org/10.1016/j.psyneuen.2018.03.005 - DOI - PubMed
    1. André C, Dinel AL, Ferreira G, Layé S, Castanon N (2014) Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2, 3-dioxygenase activation. Brain Behav Immun 41:10–21. https://doi.org/10.1016/j.bbi.2014.03.012 - DOI - PubMed
    1. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M (2005) IKK-β links inflammation to obesity-induced insulin resistance. Nat Med 11(2):191. https://doi.org/10.1038/nm1185 - DOI - PubMed
    1. Boitard C, Etchamendy N, Sauvant J, Aubert A, Tronel S, Marighetto A, Layé S, Ferreira G (2012) Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice. Hippocampus. 22(11):2095–2100. https://doi.org/10.1002/hipo.22032 - DOI - PubMed

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