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. 1987 May;207(2-3):517-8.
doi: 10.1007/BF00331625.

Nonsense suppression context effects in Escherichia coli bacteriophage T4

P Edelmann, R Martin, J Gallant

Nonsense suppression context effects in Escherichia coli bacteriophage T4

P Edelmann et al. Mol Gen Genet. 1987 May.

Abstract

Nonsense suppression by supE44 has been examined in a collection of 14 T4 gene 22 and gene 23 UAG mutants, for which the precise gene location is known. In concordance with previous studies, UAG followed by a pyrimidine was inefficiently suppressed. However, among positions with similar 3' nucleotides, there was considerable variation in suppression efficiency. The competition between supE44 and Release Factor 1 (RF 1) was also investigated following the introduction of a multicopy RF 1 plasmid. An inverse relationship between the efficiency of suppression and RF 1 competition was observed.

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