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Review
. 2020 Nov;9(21):8074-8085.
doi: 10.1002/cam4.3295. Epub 2020 Oct 7.

EO771, is it a well-characterized cell line for mouse mammary cancer model? Limit and uncertainty

Augustin Le Naour  1 , Adrien Rossary  1 , Marie-Paule Vasson  1   2
Affiliations
Review

EO771, is it a well-characterized cell line for mouse mammary cancer model? Limit and uncertainty

Augustin Le Naour et al. Cancer Med. 2020 Nov.

Abstract

Among mouse mammary tumor models, syngeneic cell lines present an advantage for the study of immune response. However, few of these models are well characterized. The tumor line EO771 is derived from spontaneous breast cancer of C57BL/6 mice. These cells are widely used but are referenced under different names: EO771, EO 771, and E0771. The characteristics of the EO771 cells are well described but some data are contradictory. This cell line presents the great interest of developing an immunocompetent neoplastic model using an orthotopic implantation reflecting the mammary tumors encountered in breast cancer patients. This review presents the phenotype characteristics of EO771 and its sensitivity to nutrients and different therapies such as radiotherapy, chemotherapy, hormone therapy, and immunotherapy.

Keywords: antineoplastic agents; breast neoplasms; hormonal receptors; inbred C57BL; mice; murine cell line.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Characteristics of the EO771 cell line and tumor bearing in C57BL/6 mice. Numerous publications have made it possible to refine the phenotype of the EO771 line. This cell line could be considered as a luminal B type mammary cancer. Tumor‐bearing mice models are well‐known and sensitive to explore numerous therapeutic strategies. After injection of EO771 cells, the major metastatic dissemination sites are in the brain, the lung, the intestine, and the peritoneal cavity
See this image and copyright information in PMC

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