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Review
. 2020 Nov;170(15-16):403-409.
doi: 10.1007/s10354-020-00783-w. Epub 2020 Oct 7.

Hemiagenesis of the thyroid gland detected by coincidence-what is the clinical relevance? : Case report and review of the literature

Peter Mikosch  1   2 , Verena Weixlbaumer  3 , Michael Irrgang  3 , Adrian Aistleitner  3 , Eva Trifina-Mikosch  3
Affiliations
Review

Hemiagenesis of the thyroid gland detected by coincidence-what is the clinical relevance? : Case report and review of the literature

Peter Mikosch et al. Wien Med Wochenschr. 2020 Nov.

Abstract
in English, German

Hemiagenesis of the thyroid gland (THA) represents a rare congenital anomaly. It is characterized by the absence of one thyroid lobe, and sometimes the isthmus as well. It can occur with all kinds of other thyroid pathologies that may be present in the remaining thyroid lobe. A case of a 21-year-old male patient is presented; he sought a thyroid consultation because of hair loss, fatigue, and problems concentrating, thus raising the suspicion of hypothyroidism. Thyroid function was normal, but sonography of the thyroid gland revealed THA of the left lobe and the isthmus. The current knowledge concerning the genesis and the clinical consequences of THA are discussed based on the current literature.

Die Hemiagenesie der Schilddrüse (THA) stellt eine seltene Anlageanomalie dar und ist durch das Fehlen eines Schilddrüsenlappens, manchmal auch des Isthmus, charakterisiert. Die Veränderung kann zusammen mit allen anderen Erkrankungen der Schilddrüse vorkommen. Es wird der Fall eines 21-jährigen männlichen Patienten vorgestellt, der wegen Haarausfall, Müdigkeit und Konzentrationsschwierigkeiten eine Schilddrüsensprechstunde aufsuchte. Es bestand der Verdacht auf eine Schilddrüsenunterfunktion. Die Schilddrüsenfunktion war normal, aber die Sonographie der Schilddrüse ergab ein THA des linken Lappens und Isthmus. Aktuelle Erkenntnisse zur Genese und mögliche klinische Konsequenzen einer THA werden auf der Basis der Literatur zur THA diskutiert.

Keywords: Clinical impact of thyroid dysgenesis; Hypothyroidism; Scintigraphy; Sonography; Thyroid development.

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Conflict of interest statement

P. Mikosch, V. Weixlbaumer, M. Irrgang, A. Aistleitner, and E. Trifina-Mikosch declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
99mTc-pertechnetate scintigraphy: homogeneous tracer accumulation over the right thyroid lobe. There is no tracer accumulation within the left side of the thyroid bed, thus proving the diagnosis of thyroid hemiagenesis. Furthermore, no ectopic tracer accumulation is seen, thus excluding other ectopic thyroid tissue
See this image and copyright information in PMC

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