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. 2021 Jan 1;116(1):206-209.
doi: 10.14309/ajg.0000000000000954.

Risk Factors for Delta Hepatitis in a North American Cohort: Who Should Be Screened?

Ben L Da  1 , Farial Rahman  1 , Walter C Lai  1 , David E Kleiner  2 , Theo Heller  1 , Christopher Koh  1
Affiliations

Risk Factors for Delta Hepatitis in a North American Cohort: Who Should Be Screened?

Ben L Da et al. Am J Gastroenterol. .

Abstract

Introduction: The American Association for the Study of Liver Diseases recommends hepatitis D virus (HDV) screening in certain high-risk groups; however, the effectiveness is unknown.

Methods: A study of North American patients with hepatitis B (HBV) referred to the NIH was performed to identify risk factors associated with HDV infection. Active HDV was "confirmed" by serum HDV RNA or histologic HDV antigen staining.

Results: Six hundred fifty-two were studied, of which 91 were HDV "confirmed." Independent risk factors for HDV included: intravenous drug users, HBV-DNA <2,000 IU/mL, alanine aminotransferase >40 U/L, and HDV endemic country of origin.

Disussion: North American patients with HBV and significant risk factors should be screened for HDV.

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Conflict of interest statement

Conflict of interest statement: The authors have no relevant conflicts of interest.

References

    1. Sureau C. The role of the HBV envelope proteins in the HDV replication cycle. Curr Top Microbiol Immunol 2006;307:113–31. - PubMed
    1. Manesis EK, Vourli G, Dalekos G, et al. Prevalence and clinical course of hepatitis delta infection in Greece: a 13-year prospective study. J Hepatol 2013;59:949–56. - PubMed
    1. Beguelin C, Moradpour D, Sahli R, et al. Hepatitis delta-associated mortality in HIV/HBV-coinfected patients. J Hepatol 2017;66:297–303. - PubMed
    1. Chen HY, Shen DT, Ji DZ, et al. Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis. Gut 2018. - PubMed
    1. Kushner T, Serper M, Kaplan DE. Delta hepatitis within the Veterans Affairs medical system in the United States: Prevalence, risk factors, and outcomes. J Hepatol 2015;63:586–92. - PMC - PubMed

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