Disregard the reported data from the HYGIA project: blood pressure medication not to be routinely dosed at bedtime

Affiliations

¹ Department of Clinical Pharmacology and Toxicology, Charité University Medicine, Berlin, Germany.
² Department of Cardiology, University of Oslo, Ullevaal Hospital, Oslo, Norway.
³ Service of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁴ Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
⁵ Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
⁶ University of Milano-Bicocca, Milan, Italy.

Editorial

Reinhold Kreutz et al. J Hypertens. 2020 Nov.

. 2020 Nov;38(11):2144-2145.

doi: 10.1097/HJH.0000000000002671.

¹ Department of Clinical Pharmacology and Toxicology, Charité University Medicine, Berlin, Germany.
² Department of Cardiology, University of Oslo, Ullevaal Hospital, Oslo, Norway.
³ Service of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁴ Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
⁵ Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
⁶ University of Milano-Bicocca, Milan, Italy.

No abstract available

References

1. Hermida RC, Crespo JJ, Dominguez-Sardina M, Otero A, Moya A, Rios MT, et al. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J 2019; 20:97.
1. Hermida RC. Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: rationale and design of the Hygia Project. Chronobiol Int 2016; 33:906–936.
1. Hermida RC, Ayala DE, Mojon A, Fernandez JR. Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol Int 2010; 27:1629–1651.
1. Pierdomenico SD, Bucci A, Costantini F, Lapenna D, Cuccurullo F, Mezzetti A. Circadian blood pressure changes and myocardial ischemia in hypertensive patients with coronary artery disease. J Am Coll Cardiol 1998; 31:1627–1634.
1. Kario K, Pickering TG, Matsuo T, Hoshide S, Schwartz JE, Shimada K. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension 2001; 38:852–857.