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Case Reports
. 2020 Sep 30:62:e68.
doi: 10.1590/S1678-9946202062068. eCollection 2020.

Calvarial tuberculosis: two cases in children

Clemax Couto Sant'Anna  1 , Pedro Luiz Ferreira Perinei  2 , Ana Carolina Machado de Pessôa  2 , Ekaterini Goudouris  1 , Ana Cristina Cisne Frota  2
Affiliations
Case Reports

Calvarial tuberculosis: two cases in children

Clemax Couto Sant'Anna et al. Rev Inst Med Trop Sao Paulo. .

Abstract

Tuberculosis of the skull or calvarial tuberculosis (CTB) is rare. The literature until 2019 reported less than 60 cases of CTB in childhood. The authors describe two patients with CTB associated with other manifestations of TB, such as: spine and rib injuries, peripheral adenopathy, hepatic and splenic involvement who improved with chemotherapy. The patients were a four-year-old and an eight-year-old child, whose diagnoses were confirmed by histopathological, bacteriological or molecular investigation. Both were not infected with the human immunodeficiency virus (HIV) and did not need orthopedic treatment.

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Conflict of interest statement

CONFLICT OF INTERESTS

None were declared.

Figures

Figure 1
Figure 1. Cranial CT with reconstruction: multiple lytic lesions on the external board of the left frontal region.
Figure 2
Figure 2. Areas of necrosis (*) in the center of bone trabeculae (T) involved by chronic inflammatory reaction - HE X 100.
Figure 3
Figure 3. Cranial CT: frontal lytic lesion in the midline with a diameter of 2 cm and a thickness of 0.7 cm.
See this image and copyright information in PMC

References

    1. Dawar P, Gupta DK, Sharma BS, Jyakumar A, Gamanagatti S. Extensive calvarial tuberculosis presenting as exophytic ulcerated growth on scalp in an infant: an interesting case report with review of literature. Childs Nerv Syst. 2013;29:1215–1218. - PubMed
    1. Datta SG, Bhatnagar V, Pan S, Mehta R, Sharma C. Primary calvarial tuberculosis: a report of three cases. Br J Neurosurg. 2019;33:196–201. - PubMed
    1. Mukherjee KK, Kaushik R, Nada R, Khosla VK, Khandelwal N, Kak VK. Calvarial tuberculosis. Surg Neurol. 2002;57:195–202. - PubMed
    1. Shah JR. Calvarial tuberculosis features in 3 cases. 2West Engl Med J. 2013;112
    1. Das S, Nayar A, Paul DK, Basu S, Sen S, Bhattacharya M, et al. Calvarial tuberculosis with multiple intracranial tuberculomas: a rare association in a severely malnourished child with disseminated tuberculosis. J Pediatr Infect Dis. 2016;11:42–47.

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