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. 2020 Oct 6;32(4):509-511.
doi: 10.1016/j.cmet.2020.09.015.

Language of a Long-Term Relationship: Bacterial Inositols and the Intestinal Epithelium

Antonella Fazio  1 , Philip Rosenstiel  2
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Language of a Long-Term Relationship: Bacterial Inositols and the Intestinal Epithelium

Antonella Fazio et al. Cell Metab. .
Free article

Abstract

The exact principles guiding host-microbe homeostasis in the intestinal tract remain obscure. In a recent issue of Nature, Wu et al. (2020) describe that bacterial-derived inositols are an important principle that shapes regenerative properties of the colonic epithelium. The metabolites activate HDAC3, which represents an important part of the epigenetic machinery.

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