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Review
. 2020 Oct 5;10(10):1970.
doi: 10.3390/nano10101970.

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Humaira Idrees  1 , Syed Zohaib Javaid Zaidi  2 , Aneela Sabir  1 , Rafi Ullah Khan  1   2 , Xunli Zhang  3 , Sammer-Ul Hassan  3
Affiliations
Review

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Humaira Idrees et al. Nanomaterials (Basel). .

Abstract

Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

Keywords: biodegradable; drug delivery; nanoparticles; pharmaceutical; polymers.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Representation of the general method of synthesis/preparation of nanoparticles.
Figure 1
Figure 1
Schematic of nanomedicines: nanospheres and nanocapsules.
Figure 2
Figure 2
Schematic of polymer classification. Reference is taken from [35]. Copyright ©2019, Elsevier.
Figure 3
Figure 3
Structure of chitosan.
Figure 4
Figure 4
Shows the formation of chitosan nanoparticles modified with tripolyphosphate (TPP)-loaded letrozole [52]. Copyright ©2017, Elsevier.
Figure 5
Figure 5
Types of alginate blocs: M = mannuronic acid; G = guluronic acid [75].
Figure 6
Figure 6
Structure of albumin [8]. Note that the oxygen atoms of almost all the carboxyl groups of amino acids are not shown in the structure. Copyright ©2019, Elsevier.
Figure 7
Figure 7
The successful use of albumin and an albumin nanoparticle (Abraxane) for cancer treatment [89]. Copyright ©2020, Elsevier.
Figure 8
Figure 8
The structure of hyaluronic acid.
See this image and copyright information in PMC

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