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. 2020 Oct 7;20(1):397.
doi: 10.1186/s12886-020-01668-7.

Short-term changes in the anterior segment and retina after small incision lenticule extraction

Yanwei Chen  1 , Huaping Liao  1 , Yue Sun  1 , Xi Shen  2
Affiliations

Short-term changes in the anterior segment and retina after small incision lenticule extraction

Yanwei Chen et al. BMC Ophthalmol. .

Abstract

Background: To analyse short-term changes in the anterior segment and retina after small incision lenticule extraction (SMILE).

Methods: Patients with myopia scheduled for SMILE were recruited from Ruijin Hospital, Shanghai, China. Basic patient information such as age, sex, and refractive errors was recorded. Ocular measurements were taken before surgery, and 1 day and 1 week after surgery; they included axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), white to white (WTW), pupil diameter (PD), macular thickness (MT), ganglion cell layer thickness (GCL), retinal nerve fiber layer thickness (RNFL), choroidal thickness (CT), macular vessel density, and optic disc vessel density.

Results: Sixty-one eyes of 31 patients were selected for this study. AL, CCT, ACD, and postoperative PD were significantly reduced (p < 0.05), while LT was thickened after surgery (p < 0.05). MT at the fovea decreased 1 day and 1 week after surgery (p < 0.05). GCL showed no significant changes after surgery. RNFL was unchanged 1 day after surgery, but the inferior sector was thickened 1 week after surgery. CT was thicker at the fovea 1 day after surgery and 1.0 mm from the fovea in the nasal sector 1 week after surgery. Macular vessel density was significantly decreased 1 day after surgery and most recovered in 1 week. Optic disc vessel density decreased at the peripapillary part 1 day after surgery and recovered after 1 week. ΔACD and ΔLT showed no significant correlation 1 day after surgery. ΔACD was negatively correlated with ΔLT and sphere 1 week after surgery (r = - 0.847, p < 0.000; r = - 0.398, p = 0.002). ΔLT was positively correlated with the sphere 1 week after surgery (r = 0.256, p = 0.048).

Conclusion: The anterior segment was the most affected, while the retina also underwent changes with regard to MT, RNFL, CT, macular vessel density, and peripapillary vessel density.

Keywords: Anterior segment; Optical coherence tomography angiography (OCTA); Retina; Small incision lenticule extraction.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Macular thickness map of the right eyes based on OCT
Fig. 2
Fig. 2
Ganglion cell layer thickness map of the right eyes based on OCT
Fig. 3
Fig. 3
Retinal nerve fiber layer deviation map of the right eyes based on OCT
Fig. 4
Fig. 4
Choroidal thickness measurement of the fovea (F), 0.5 mm, and 1.0 mm from the fovea in nasal and temporal respectively (N0.5, N1.0, T0.5, T1.0)
Fig. 5
Fig. 5
Vessel density map of the macular and optic disc of the right eyes based on OCTA
Fig. 6
Fig. 6
Correlation between ΔACD and ΔLT 1 week after surgery
Fig. 7
Fig. 7
Correlation between ΔACD and sphere 1 week after surgery
Fig. 8
Fig. 8
Correlation between ΔLT and sphere 1 week after surgery
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References

    1. Trokel SL, Srinivasan R, Braren B. Excimer laser surgery of the cornea. Am J Ophthalmol. 1983;96(6):710–715. doi: 10.1016/S0002-9394(14)71911-7. - DOI - PubMed
    1. Vestergaard A, Ivarsen AR, Asp S, Hjortdal JO. Small-incision lenticule extraction for moderate to high myopia: predictability, safety, and patient satisfaction. J Cataract Refract Surg. 2012;38(11):2003–2010. doi: 10.1016/j.jcrs.2012.07.021. - DOI - PubMed
    1. Blum M, Lauer AS, Kunert KS, Sekundo W. 10-Year Results of Small Incision Lenticule Extraction. J Refract Surg. 2019;35(10):618–623. doi: 10.3928/1081597X-20190826-02. - DOI - PubMed
    1. Wang D, Liu M, Chen Y, Zhang X, Xu Y, Wang J, CH T, Liu Q. Differences in the corneal biomechanical changes after SMILE and LASIK. J Refract Surg. 2014;30(10):702–707. doi: 10.3928/1081597X-20140903-09. - DOI - PubMed
    1. Chen M, Yu M, Dai J. Comparison of biomechanical effects of small incision lenticule extraction and laser-assisted subepithelial keratomileusis. Acta Ophthalmol. 2016;94(7):e586–e591. doi: 10.1111/aos.13035. - DOI - PubMed