Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol

doi:10.1007/s00520-020-05813-2

. 2021 Jun;29(6):3009-3016.

doi: 10.1007/s00520-020-05813-2. Epub 2020 Oct 8.

Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol

Jordan M Cloyd^{1

2}, Sarah Hyman³, Tanya Huwig⁴, Christina Monsour⁵, Heena Santry⁵, Celia Wills⁶, Allan Tsung⁵, John F P Bridges^{5

3

4}

Affiliations

¹ Department of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA. jordan.cloyd@osumc.edu.
² Division of Surgical Oncology, The Ohio State University Wexner Medical Center, 410 W 10th Ave, N-907 Doan Hall, Columbus, OH, 43210, USA. jordan.cloyd@osumc.edu.
³ College of Public Health, The Ohio State Wexner Medical Center, Columbus, OH, USA.
⁴ Department of Biomedical Informatics, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
⁵ Department of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
⁶ College of Nursing, The Ohio State Wexner Medical Center, Columbus, OH, USA.

PMID: 33030596
DOI: 10.1007/s00520-020-05813-2

Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol

Jordan M Cloyd et al. Support Care Cancer. 2021 Jun.

. 2021 Jun;29(6):3009-3016.

doi: 10.1007/s00520-020-05813-2. Epub 2020 Oct 8.

Authors

Jordan M Cloyd^{1

2}, Sarah Hyman³, Tanya Huwig⁴, Christina Monsour⁵, Heena Santry⁵, Celia Wills⁶, Allan Tsung⁵, John F P Bridges^{5

3

4}

Affiliations

¹ Department of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA. jordan.cloyd@osumc.edu.
² Division of Surgical Oncology, The Ohio State University Wexner Medical Center, 410 W 10th Ave, N-907 Doan Hall, Columbus, OH, 43210, USA. jordan.cloyd@osumc.edu.
³ College of Public Health, The Ohio State Wexner Medical Center, Columbus, OH, USA.
⁴ Department of Biomedical Informatics, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
⁵ Department of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
⁶ College of Nursing, The Ohio State Wexner Medical Center, Columbus, OH, USA.

PMID: 33030596
DOI: 10.1007/s00520-020-05813-2

Abstract

Purpose: Neoadjuvant therapy (NT) is increasingly being offered to patients with pancreatic ductal adenocarcinoma (PDAC) prior to surgical resection. However, the experience and quality of life (QOL) of patients undergoing NT are poorly understood.

Methods: A systematic review of the Cinahl, Embase, Medline, Pubmed, Scopus, and Web of Science databases was conducted to evaluate the available literature pertaining to the experience and QOL of patient's undergoing NT for PDAC.

Results: Among 6041 articles screened, only six met criteria for full-text review including three prospective clinical trials of NT with QOL secondary endpoints. Overall, global QOL during or following NT did not significantly change from baseline. Pain scores seemed to improve during NT while the impact of NT on physical functioning varied across studies. No studies were identified evaluating other aspects of the patient experience.

Conclusion: Although NT appears to have a minor impact on the QOL of patients with PDAC, this systematic review identified significant evidence gaps in the literature. A protocol of a prospective observational cohort study utilizing a digital smartphone app that aims to evaluate the patient experience and longitudinal QOL of patients with PDAC undergoing NT is presented.

Keywords: Palliative care; Pancreatic ductal adenocarcinoma; Patient preferences; Patient-reported outcomes; Psychological impact; Supportive care.

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Characterizing the patient experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma: A qualitative study.
Stevens L, Brown ZJ, Zeh R, Monsour C, Wells-Di Gregorio S, Santry H, Ejaz AM, Pawlik TM, Cloyd JM. Stevens L, et al. World J Gastrointest Oncol. 2022 Jun 15;14(6):1175-1186. doi: 10.4251/wjgo.v14.i6.1175. World J Gastrointest Oncol. 2022. PMID: 35949220 Free PMC article.
Assessment of a collaborative treatment model for trimodal management of esophageal cancer.
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Patient Perceptions of Care Coordination during Neoadjuvant Therapy for Gastrointestinal Cancers: A Mixed Methods Analysis.
Bath NM, Palettas M, Stevens L, Sarna A, Ejaz A, Kim A, Pawlik TM, Cloyd JM. Bath NM, et al. J Gastrointest Cancer. 2024 Jun;55(2):862-868. doi: 10.1007/s12029-024-01030-w. Epub 2024 Feb 14. J Gastrointest Cancer. 2024. PMID: 38351391 Free PMC article.
Multi-specialty physician perspectives on barriers and facilitators to the use of neoadjuvant therapy for pancreatic ductal adenocarcinoma.
Schreiber L, Zeh R, Monsour C, Ejaz A, Tsung A, Pawlik TM, Miller E, Noonan A, Krishna SG, Santry H, Cloyd JM. Schreiber L, et al. HPB (Oxford). 2022 Jun;24(6):833-840. doi: 10.1016/j.hpb.2021.10.010. Epub 2021 Oct 25. HPB (Oxford). 2022. PMID: 34764009 Free PMC article.
The Association Between Patient-Reported Outcomes and Surgical Attrition During Neoadjuvant Therapy for Gastrointestinal Malignancies.
Shannon AH, Palettas M, Sarna A, Huang E, Kneuertz PJ, Dillhoff M, Ejaz A, Pawlik TM, Cloyd JM. Shannon AH, et al. J Gastrointest Cancer. 2024 Dec 11;56(1):31. doi: 10.1007/s12029-024-01153-0. J Gastrointest Cancer. 2024. PMID: 39661262

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References

1. Siegel RL, Miller KD, Jemal A (2018) Cancer statistics. CA Cancer J Clin 68:7–30. https://doi.org/10.3322/caac.21442 - DOI
1. Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, Weiss MJ, Zheng L, Wolfgang CL, He J (2017) Patterns, Timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg 267:936–945. https://doi.org/10.1097/SLA.0000000000002234 - DOI
1. Cloyd J, Shen C, Santry H et al (2020) Disparities in the use of neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma. J Natl Compr Cancer Netw 18(5):1–8
1. Bilimoria KY, Bentrem DJ, Ko CY, Tomlinson JS, Stewart AK, Winchester DP, Talamonti MS (2007) Multimodality therapy for pancreatic cancer in the U.S. : utilization, outcomes, and the effect of hospital volume. Cancer 110:1227–1234. https://doi.org/10.1002/cncr.22916 - DOI - PubMed
1. Altman AM, Wirth K, Marmor S, Lou E, Chang K, Hui JYC, Tuttle TM, Jensen EH, Denbo JW (2019) Completion of adjuvant chemotherapy after upfront surgical resection for pancreatic cancer is uncommon yet associated with improved survival. Ann Surg Oncol 26:4108–4116. https://doi.org/10.1245/s10434-019-07602-6 - DOI - PubMed

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[1] Siegel RL, Miller KD, Jemal A (2018) Cancer statistics. CA Cancer J Clin 68:7–30. https://doi.org/10.3322/caac.21442 - DOI

[2] Siegel RL, Miller KD, Jemal A (2018) Cancer statistics. CA Cancer J Clin 68:7–30. https://doi.org/10.3322/caac.21442 - DOI

[3] Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, Weiss MJ, Zheng L, Wolfgang CL, He J (2017) Patterns, Timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg 267:936–945. https://doi.org/10.1097/SLA.0000000000002234 - DOI

[4] Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, Weiss MJ, Zheng L, Wolfgang CL, He J (2017) Patterns, Timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg 267:936–945. https://doi.org/10.1097/SLA.0000000000002234 - DOI

[5] Cloyd J, Shen C, Santry H et al (2020) Disparities in the use of neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma. J Natl Compr Cancer Netw 18(5):1–8

[6] Cloyd J, Shen C, Santry H et al (2020) Disparities in the use of neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma. J Natl Compr Cancer Netw 18(5):1–8

[7] Bilimoria KY, Bentrem DJ, Ko CY, Tomlinson JS, Stewart AK, Winchester DP, Talamonti MS (2007) Multimodality therapy for pancreatic cancer in the U.S. : utilization, outcomes, and the effect of hospital volume. Cancer 110:1227–1234. https://doi.org/10.1002/cncr.22916 - DOI - PubMed

[8] Bilimoria KY, Bentrem DJ, Ko CY, Tomlinson JS, Stewart AK, Winchester DP, Talamonti MS (2007) Multimodality therapy for pancreatic cancer in the U.S. : utilization, outcomes, and the effect of hospital volume. Cancer 110:1227–1234. https://doi.org/10.1002/cncr.22916 - DOI - PubMed

[9] Altman AM, Wirth K, Marmor S, Lou E, Chang K, Hui JYC, Tuttle TM, Jensen EH, Denbo JW (2019) Completion of adjuvant chemotherapy after upfront surgical resection for pancreatic cancer is uncommon yet associated with improved survival. Ann Surg Oncol 26:4108–4116. https://doi.org/10.1245/s10434-019-07602-6 - DOI - PubMed

[10] Altman AM, Wirth K, Marmor S, Lou E, Chang K, Hui JYC, Tuttle TM, Jensen EH, Denbo JW (2019) Completion of adjuvant chemotherapy after upfront surgical resection for pancreatic cancer is uncommon yet associated with improved survival. Ann Surg Oncol 26:4108–4116. https://doi.org/10.1245/s10434-019-07602-6 - DOI - PubMed

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Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol

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Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol

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