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Review
. 2021 Jun 1;42(2):109-117.
doi: 10.1097/PAF.0000000000000621.

Medicolegal Implications of Biphasic Anaphylaxis

Ugo Da Broi  1 , Carlo Moreschi  1 , Giulia Marega  1 , Rexson Tse, Jack Garland  2 , Benjamin Ondruschka  3 , Cristian Palmiere  4
Affiliations
Review

Medicolegal Implications of Biphasic Anaphylaxis

Ugo Da Broi et al. Am J Forensic Med Pathol. .

Abstract

Biphasic anaphylaxis is an uncommon IgE-mediated condition whose pathophysiological mechanisms, risk factors, and predictive signs are not properly understood. Fortunately, the lethality of biphasic anaphylaxis, although probably underestimated, is low. Preventive clinical measures for biphasic anaphylaxis are neither standardized nor commonly applied. Furthermore, there are no laboratory protocols or anaphylactic markers to help identify the onset of biphasic anaphylaxis in clinical settings. The aim of this review is to highlight the medicolegal difficulties facing coroners and forensic pathologists in terms of the diagnosis and assessment of harm for victims and survivors of biphasic anaphylaxis.

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Conflict of interest statement

The authors report no conflict of interest.

References

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