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Meta-Analysis
. 2022 Mar;28(2):275-283.
doi: 10.1111/odi.13671. Epub 2020 Oct 25.

The budding and depth of invasion model in oral cancer: A systematic review and meta-analysis

Awais Wahab  1   2 , Oona Onkamo  3 , Matti Pirinen  4   5   6 , Alhadi Almangush  1   7   8   9 , Tuula Salo  2   10
Affiliations
Meta-Analysis

The budding and depth of invasion model in oral cancer: A systematic review and meta-analysis

Awais Wahab et al. Oral Dis. 2022 Mar.

Abstract

Background: Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta-analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC.

Methods: Databases including Ovid MEDLINE, PubMed, Scopus and Web of Science were searched for articles that studied the BD model as a prognosticator in OSCC. PICO search strategy was "In OSCC patients, does BD model have a prognostic power?" We used the reporting recommendations for tumour marker prognostic studies (REMARK) criteria to evaluate the quality of studies eligible for systematic review and meta-analysis.

Results: Nine studies were relevant as they analysed the BD model for prognostication of OSCC. These studies used either haematoxylin and eosin (HE) or pan-cytokeratin (PCK)-stained resected sections of OSCC. Our meta-analysis showed a significant association of BD model with OSCC disease-free survival (hazard ratio = 2.02; 95% confidence interval = 1.44-2.85).

Conclusions: The BD model is a simple and reliable prognostic indicator for OSCC. Evaluation of the BD model from HE- or PCK-stained sections could facilitate individualized treatment planning for OSCC patients.

Keywords: BD model; depth of invasion; oral squamous cell carcinoma; prognostication; survival analysis; tumour budding.

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