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Comment
. 2020 Oct 31;396(10260):e64-e65.
doi: 10.1016/S0140-6736(20)32079-1. Epub 2020 Oct 5.

Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral

Carsten Dittmayer  1 , Jenny Meinhardt  2 , Helena Radbruch  2 , Josefine Radke  3 , Barbara Ingold Heppner  4 , Frank L Heppner  5 , Werner Stenzel  2 , Gudrun Holland  6 , Michael Laue  6
Affiliations
Comment

Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral

Carsten Dittmayer et al. Lancet. .
No abstract available

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Figures

Figure
Figure
SARS-CoV-2 ultrastructural morphology in an autopsy lung specimen Characteristic substructure of SARS-CoV-2 particles at high magnification obtained by electron microscopy (black arrows point to well preserved coronavirus) in an endothelial cell (A) and a type II pneumocyte (B, E). Although characteristic coronavirus morphology might be negatively affected by autolysis of cells, generally complicating cell type assessment, we found these coronavirus particles in a patient with a post-mortem interval of 30 h. Intracellular coronavirus particles are typically located within membrane compartments (A-D; white arrows). A heterogeneous, electron-dense, partly granular interior with ribonucleoprotein can be differentiated (C–D; white arrowheads), envelope membranes of coronavirus are well resolved, and some particles show delicate surface projections (ie, spikes; C–D; black arrowheads). In a type II pneumocyte (E), lamellar bodies are indicated by the # symbol, and compartments with numerous coronavirus particles are indicated by the * symbol. RT-PCR of this lung specimen revealed a high SARS-CoV-2 RNA load. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2
See this image and copyright information in PMC

Comment in

  • Using EM data to understand COVID-19 pathophysiology.
    Dolhnikoff M, Duarte-Neto AN, Saldiva PHN, Caldini EG. Dolhnikoff M, et al. Lancet. 2021 Jan 16;397(10270):196-197. doi: 10.1016/S0140-6736(21)00034-9. Lancet. 2021. PMID: 33453779 Free PMC article. No abstract available.

Comment on

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