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Comment
. 2020 Oct 7;28(4):499-501.
doi: 10.1016/j.chom.2020.09.010.

Mining the Antibody Repertoire for Solutions to SARS-CoV-2

Wenzhao Meng  1 , Aaron M Rosenfeld  1 , Eline T Luning Prak  2
Affiliations
Comment

Mining the Antibody Repertoire for Solutions to SARS-CoV-2

Wenzhao Meng et al. Cell Host Microbe. .

Abstract

In this issue of Cell Host & Microbe, Nielsen and colleagues sequence antibody repertoires of patients with severe COVID-19 to reveal potentially convergent features on the background of a larger, polyclonal response. Their findings suggest that, as databases improve, it may be possible to monitor virus-specific B cells after infection or vaccination using antibody sequencing.

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Conflict of interest statement

Declaration of Interests E.T.L.P. is a paid consultant for Enpicom, B.V., a software company that develops tools for data analysis and visualization of immune repertoires.

Comment on

  • Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.
    Nielsen SCA, Yang F, Jackson KJL, Hoh RA, Röltgen K, Jean GH, Stevens BA, Lee JY, Rustagi A, Rogers AJ, Powell AE, Hunter M, Najeeb J, Otrelo-Cardoso AR, Yost KE, Daniel B, Nadeau KC, Chang HY, Satpathy AT, Jardetzky TS, Kim PS, Wang TT, Pinsky BA, Blish CA, Boyd SD. Nielsen SCA, et al. Cell Host Microbe. 2020 Oct 7;28(4):516-525.e5. doi: 10.1016/j.chom.2020.09.002. Epub 2020 Sep 3. Cell Host Microbe. 2020. PMID: 32941787 Free PMC article.

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