Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May;26(3):699-709.
doi: 10.1007/s10741-020-10036-y. Epub 2020 Oct 8.

Vitamin C: historical perspectives and heart failure

Akshi Malik  1 , Ashim K Bagchi  1 , Kartik Vinayak  1 , Gauri Akolkar  2 , Jan Slezak  3 , Adriane Belló-Klein  4 , Davinder S Jassal  1   5 , Pawan K Singal  6
Affiliations
Review

Vitamin C: historical perspectives and heart failure

Akshi Malik et al. Heart Fail Rev. 2021 May.

Erratum in

Abstract

Vitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes. It has received much attention due to its ability in limiting reactive oxygen species, oxidative stress, and nitrosative stress, as well as it helps to maintain some of the normal metabolic functions of the cell. However, over 140 clinical trials using Vit C in different pathological conditions such as myocardial infarction, gastritis, diabetes, hypertension, stroke, and cancer have yielded inconsistent results. Such a divergence calls for new strategies to establish practical significance of Vit C in heart failure or even in its prevention. For a better understanding of Vit C functioning, it is important to revisit its transport across the cell membrane and subcellular interactions. In this review, we have highlighted some historical details of Vit C and its transporters in the heart with a particular focus on heart failure in cancer chemotherapy.

Keywords: Doxorubicin; Nitric oxide; Nitric oxide synthases (NOS); Tetrahydrobiopterin (BH4); Vit C transporters.

PubMed Disclaimer

References

    1. Carr AC, Frei B (1999) Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 69:1086–1107 - PubMed
    1. Drake VJ, Frei B (2011) In: Herrmann W, Obeid R (eds) Vitamins in the prevention of human diseases. Walter de Gruyter, Berlin, pp 347–362
    1. Cook NR, Albert CM, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, Buring JE, Manson J (2007) A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women - results from the Women’s Antioxidant Cardiovascular Study. Arch Intern Med 167:1610–1618 - PubMed - PMC
    1. Galang N, Sasaki H, Maulik N (2000) Apoptotic cell death during ischemia/reperfusion and its attenuation by antioxidant therapy. Toxicology 148:111–118 - PubMed
    1. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briançon S (2004) The SU.VI.MAX study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 164:2335–2242

Publication types

LinkOut - more resources