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. 2021 Jan;47(1):116-118.
doi: 10.1007/s00134-020-06241-w. Epub 2020 Oct 9.

Neuroanatomical substrates of generalized brain dysfunction in COVID-19

Virginia F J Newcombe  1   2 , Lennart R B Spindler  3   4 , Tilak Das  5 , Stefan Winzeck  3   6 , Kieren Allinson  7 , Emmanuel A Stamatakis  3   8   4 , David K Menon  9   10 ; Cambridge NeuroCovid Imaging Collaborators
Collaborators, Affiliations

Neuroanatomical substrates of generalized brain dysfunction in COVID-19

Virginia F J Newcombe et al. Intensive Care Med. 2021 Jan.
No abstract available

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Conflict of interest statement

All the authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Quantitative DTI. Panel A shows boxplots of mean difusivity (MD) in gray matter regions where COVID-19 patients show significant diferences compared to age- and sex-matched control subjects. Panel B shows the group wise comparison of parcellated white matter tracts. Tracts in color (not gray) have significantly lower fractional anisotropy (FA) in the COVID-19 cases when compared to age and sex-matched controls. The color coding reflects directionality of fibers, with green denoting anterior/posterior, blue superior/inferior, and red right/left directionality. Histology of the dorsal medulla (patient 2). Panel C: CD3 (x 200 magnification) immunohistochemistry showing a moderate parenchymal infiltrate of T-cells. Panel D: CD68 immunohistochemistry showing micogliosis with microglial nodules
See this image and copyright information in PMC

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