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Observational Study
. 2021 Jul 1;73(1):1-11.
doi: 10.1093/cid/ciaa1535.

Stop COVID Cohort: An Observational Study of 3480 Patients Admitted to the Sechenov University Hospital Network in Moscow City for Suspected Coronavirus Disease 2019 (COVID-19) Infection

Daniel Munblit  1   2   3 , Nikita A Nekliudov  1 , Polina Bugaeva  1 , Oleg Blyuss  1   4 , Maria Kislova  1 , Ekaterina Listovskaya  1 , Aysylu Gamirova  1 , Anastasia Shikhaleva  1 , Vladimir Belyaev  5 , Peter Timashev  6   7   8 , John O Warner  2 , Pasquale Comberiati  9 , Christian Apfelbacher  10 , Evgenii Bezrukov  11 , Mikhail E Politov  12 , Andrey Yavorovskiy  12 , Ekaterina Bulanova  12 , Natalya Tsareva  13 , Sergey Avdeev  13 , Valentina A Kapustina  14 , Yuri I Pigolkin  15 , Emmanuelle A Dankwa  16 , Christiana Kartsonaki  17 , Mark G Pritchard  18   19 , Victor Fomin  20 , Andrey A Svistunov  20 , Denis Butnaru  20 , Petr Glybochko  20 ; Sechenov StopCOVID Research Team
Collaborators, Affiliations
Observational Study

Stop COVID Cohort: An Observational Study of 3480 Patients Admitted to the Sechenov University Hospital Network in Moscow City for Suspected Coronavirus Disease 2019 (COVID-19) Infection

Daniel Munblit et al. Clin Infect Dis. .

Erratum in

Abstract

Background: The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking.

Methods: We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020.

Results: Of the 4261 patients hospitalized for suspected COVID-19, outcomes were available for 3480 patients (median age, 56 years; interquartile range, 45-66). The most common comorbidities were hypertension, obesity, chronic cardiovascular disease, and diabetes. Half of the patients (n = 1728) had a positive reverse transcriptase-polymerase chain reaction (RT-PCR), while 1748 had a negative RT-PCR but had clinical symptoms and characteristic computed tomography signs suggestive of COVID-19. No significant differences in frequency of symptoms, laboratory test results, and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR. In a multivariable logistic regression model the following were associated with in-hospital mortality: older age (per 1-year increase; odds ratio, 1.05; 95% confidence interval, 1.03-1.06), male sex (1.71; 1.24-2.37), chronic kidney disease (2.99; 1.89-4.64), diabetes (2.1; 1.46-2.99), chronic cardiovascular disease (1.78; 1.24-2.57), and dementia (2.73; 1.34-5.47).

Conclusions: Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features was sufficient to diagnose COVID-19 infection, indicating that laboratory testing is not critical in real-life clinical practice.

Keywords: COVID-19; Russia; SARS-CoV-2; cohort; mortality risk factors.

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Comment in

  • Comparison Between Hospitalized Patients Affected or Not Affected by Coronavirus Disease 2019.
    Russo A, Bellelli V, Ceccarelli G, Marincola Cattaneo F, Bianchi L, Pierro R, Russo R, Steffanina A, Pugliese F, Mastroianni CM, d'Ettorre G, Sabetta F. Russo A, et al. Clin Infect Dis. 2021 Jun 15;72(12):e1158-e1159. doi: 10.1093/cid/ciaa1745. Clin Infect Dis. 2021. PMID: 33206938 Free PMC article. No abstract available.
  • Reply to Russo et al.
    Munblit D, Nekliudov NA, Bugaeva P, Blyuss O, Timashev P, Warner JO, Comberiati P, Apfelbacher C, Politov ME, Yavorovskiy A, Avdeev S, Kapustina VA, Fomin V, Svistunov AA, Butnaru D, Glybochko P. Munblit D, et al. Clin Infect Dis. 2021 Jun 15;72(12):e1159-e1160. doi: 10.1093/cid/ciaa1746. Clin Infect Dis. 2021. PMID: 33206957 No abstract available.

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