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Review
. 2020 Nov 15;30(22):127600.
doi: 10.1016/j.bmcl.2020.127600. Epub 2020 Oct 6.

SFPH proteins as therapeutic targets for a myriad of diseases

Dong Wang  1 , Redouane Tabti  2 , Sabria Elderwish  2 , Amel Djehal  3 , Nora Chouha  4 , Franck Pinot  5 , Peng Yu  1 , Canan G Nebigil  2 , Laurent Désaubry  6
Affiliations
Review

SFPH proteins as therapeutic targets for a myriad of diseases

Dong Wang et al. Bioorg Med Chem Lett. .

Abstract

The stomatin/prohibitin/flotillin/HflK/HflC (SPFH) domain is present in an evolutionarily conserved family of proteins that regulate a myriad of signaling pathways in archaea, bacteria and eukaryotes. The most studied SPFH proteins, prohibitins, have already been targeted by different families of small molecules to induce anticancer, cardioprotective, anti-inflammatory, antiviral, and antiosteoporotic activities. Ligands of other SPFH proteins have also been identified and shown to act as anesthetics, anti-allodynia, anticancer, and anti-inflammatory agents. These findings indicate that modulators of human or bacterial SPFH proteins can be developed to treat a wide variety of human disorders.

Keywords: Allodynia; Anesthesia; Cancer; Drug discovery; Infectious diseases; Lipid rafts; Scaffold proteins.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

None
Graphical abstract
Fig. 1
Fig. 1
Representative examples of SPFH proteins ligands.
Fig. 2
Fig. 2
Overview of PHB signaling. Post-translational modifications and endogenous ligands (sphingosine-1-phosphate, DNA and long noncoding RNA) control the localization of PHBs and their interactions with signaling proteins.
Fig. 3
Fig. 3
Overview of the mechanism of action of PHB ligands in cancer cells.
Fig. 4
Fig. 4
Activation of unphoshorylated cofilin by cucurbitacinB/E leading to a severing and depolymerisation of actin filaments.
Fig. 5
Fig. 5
Inhibition of STOML3 oligomerization by OB-1/2 to inhibit Piezo channels and consequently to alleviate tactile allodynia.
See this image and copyright information in PMC

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