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Observational Study
. 2020 Nov-Dec;14(6):1927-1930.
doi: 10.1016/j.dsx.2020.09.035. Epub 2020 Oct 1.

Relation of D-dimer levels of COVID-19 patients with diabetes mellitus

Yogendra Mishra  1 , Basant Kumar Pathak  1 , Sourya Sourabh Mohakuda  1 , T V S V G K Tilak  1 , Soham Sen  1 , Harikrishnan P  1 , Rhea Singh  2 , Anchit Raj Singh  3
Affiliations
Observational Study

Relation of D-dimer levels of COVID-19 patients with diabetes mellitus

Yogendra Mishra et al. Diabetes Metab Syndr. 2020 Nov-Dec.

Abstract

Background and aims: Diabetes is a frequent comorbidity in patients with Severe COVID-19 infection associated with a worse prognosis. Hypercoagulability with elevation in D-dimer levels has been demonstrated in patients with COVID-19. This study aims to study D-dimer levels in people with diabetes compared to those without diabetes among patients with COVID-19 infection.

Methods: In this observational study 98 moderate and severely ill patients with COVID-19 infection were included at a dedicated COVID hospital. The study group was divided into patients with diabetes and without diabetes. Peak D-dimer was measured in both the groups and compared using appropriate statistical tests.

Results: In our study peak D-dimer levels were 1509 ± 2420 ng/mL (Mean ± SD) in people with diabetes and 515 ± 624 ng/mL (Mean ± SD) in patients without diabetes. Patients with diabetes had higher D-dimer levels which were statistically significant.

Conclusions: This study shows COVID-19 patients with diabetes had significantly higher D-dimer levels. Therefore, it is possible that COVID-19 infection with diabetes is more likely to cause hypercoagulable state with a worse prognosis. However clinical implications of these findings will need to be seen in further studies.

Keywords: COVID-19; D-dimer; Diabetes.

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Conflict of interest statement

Declaration of competing interest The authors declare that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow chart showing enrolment of patients for the study.
Fig. 2
Fig. 2
Box-plots of Peak D-dimer levels in COVID-19 showing a significant difference between people with diabetes and people without diabetes.
See this image and copyright information in PMC

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