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Review
. 2020 Nov;38(4):563-573.
doi: 10.1016/j.ccl.2020.07.001. Epub 2020 Sep 17.

State of the Art: No-Reflow Phenomenon

Gianluca Caiazzo  1 , Rita Leonarda Musci  2 , Lara Frediani  3 , Julia Umińska  4 , Wojciech Wanha  5 , Krzysztof J Filipiak  6 , Jacek Kubica  4 , Eliano Pio Navarese  7
Affiliations
Review

State of the Art: No-Reflow Phenomenon

Gianluca Caiazzo et al. Cardiol Clin. 2020 Nov.

Abstract

Primary percutaneous coronary intervention is the preferred reperfusion strategy for the management of acute ST-segment elevation myocardial infarction. No reflow is characterized by the inadequate myocardial perfusion of a given segment without angiographic evidence of persistent mechanical obstruction of epicardial vessels. Both pharmacologic and device-based strategies have been tested to resolve coronary no reflow. This article provides an updated overview of the no-reflow phenomenon, discussing clinical evidence and ongoing investigations of existing and novel therapeutic strategies to counteract it.

Keywords: Microvascular obstruction; No-reflow; Primary PCI.

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Conflict of interest statement

Disclosure The authors have no commercial or financial conflicts of interest; no funding has been received for this article.

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